搜索到26835篇“ COLONY“的相关文章
Denosumab combined with immunotherapy,radiotherapy,and granulocyte-macrophage colony-stimulating factor for the treatment of metastatic nasopharyngeal carcinoma:A case report
2025年
BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma(NPC).Recently,nuclear factor kappa-beta ligand(RANKL)inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption,as well as their potential to modulate immune functions and thereby enhance the efficacy of programmed cell death protein 1(PD-1)inhibitor therapy.CASE SUMMARY We present a case of a patient with NPC who developed sternal stalk metastasis and multiple bone metastases with soft tissue invasion following radical chemoradiotherapy and targeted therapy.Prior to chemotherapy,the patient experienced severe bone marrow suppression and opted out of further chemotherapy sessions.However,the patient received combination therapy,including RANKL inhibitors(denosumab)alongside PD-1,radiotherapy,and granulocyte-macrophage colonystimulating factor(PRaG)therapy(NCT05435768),and achieved 16 months of progression-free survival and more than 35 months of overall survival,without encountering any grade 2 or higher treatment-related adverse events.CONCLUSION Denosumab combined with PRaG therapy could be a new therapeutic approach for the second-line treatment in patients with bone metastases.
Wei-Wu ChenYue-Hong KongLi-Yuan Zhang
关键词:RADIOTHERAPYDENOSUMAB
A Distributed Ant Colony Optimization Applied in Edge Detection
2024年
With the rise of image data and increased complexity of tasks in edge detection, conventional artificial intelligence techniques have been severely impacted. To be able to solve even greater problems of the future, learning algorithms must maintain high speed and accuracy through economical means. Traditional edge detection approaches cannot detect edges in images in a timely manner due to memory and computational time constraints. In this work, a novel parallelized ant colony optimization technique in a distributed framework provided by the Hadoop/Map-Reduce infrastructure is proposed to improve the edge detection capabilities. Moreover, a filtering technique is applied to reduce the noisy background of images to achieve significant improvement in the accuracy of edge detection. Close examinations of the implementation of the proposed algorithm are discussed and demonstrated through experiments. Results reveal high classification accuracy and significant improvements in speedup, scaleup and sizeup compared to the standard algorithms.
Min Chen
关键词:MAPREDUCESPEEDUP
An Effective Optimization Algorithm for Ant Colony Vehicular Congestion Management
2024年
Adaptability and dynamicity are special properties of social insects derived from the decentralized behavior of the insects. Authors have come up with designs for software solution that can regulate traffic congestion in a network transportation environment. The effectiveness of various researches on traffic management has been verified through appropriate metrics. Most of the traffic management systems are centered on using sensors, visual monitoring and neural networks to check for available parking space with the aim of informing drivers beforehand to prevent traffic congestion. There has been limited research on solving ongoing traffic congestion in congestion prone areas like car park with any of the common methods mentioned. This study focus however is on a motor park, as a highly congested area when it comes to traffic. The car park has two entrance gate and three exit gates which is divided into three Isle of parking lot where cars can park. An ant colony optimization algorithm (ACO) was developed as an effective management system for controlling navigation and vehicular traffic congestion problems when cars exit a motor park. The ACO based on the nature and movement of the natural ants, simulates the movement of cars out of the car park through their nearest choice exit. A car park simulation was also used for the mathematical computation of the pheromone. The system was implemented using SIMD because of its dual parallelization ability. The result showed about 95% increase on the number of vehicles that left the motor park in one second. A clear indication that pheromones are large determinants of the shortest route to take as cars followed the closest exit to them. Future researchers may consider monitoring a centralized tally system for cars coming into the park through a censored gate being.
Tebepah TariugeTimadi Matthew
关键词:ADAPTABILITYCONGESTIONPHEROMONES
Plant allelochemicals inhibit the growth and colony formation of Microcystis被引量:1
2024年
Genus Microcystis is the most common dominant species of bloom-forming cyanobacteria.Growth and colony formation are critical processes for the occurrence of Microcystis blooms.To identify allelochemicals that can inhibit the growth and colony formation of Microcystis,Microcystis aeruginosa was cultivated and treated with various concentrations of gramine,catechol,berberine,and sanguinarine in laboratory.Results indicate that the growth,colony formation,and extracellular polysaccharides(EPS)content of Microcystis were significantly inhibited when treated with gramine,catechol,and berberine in appropriate concentrations at high iron level(6.8 mg/L).Microcystis growth was inhibited and colony formation and EPS content were promoted when treated with sanguinarine at high iron level.These findings suggest that cyanobacterial blooms can be controlled by regulating the input of gramine,catechol,and berberine.Furthermore,this study revealed that plant allelochemicals could affect the growth and morphology of algae in aquatic ecological restoration,which may be potentially important for improving water quality.
Xiao MAXueli WANGShaoqi ZHOUJianrong MAJingfu WANGJingan CHENYan ZENGQiao CHENBoqiang QINMing LI
关键词:MICROCYSTISCOLONY
基于改进蚁群算法的复杂环境路径规划
2024年
针对蚁群算法在复杂环境下难以收敛、最优值差的问题,提出了一种改进蚁群算法。引入修正策略,提出两种局部修正方法以减少无效路径。提出一种自适应信息素更新机制,将初始信息素与蚂蚁所释放的信息素区分挥发;针对每次迭代蚂蚁所释放的信息素,通过设计时变挥发因子的变化律单独挥发,得到自适应挥发强度的信息素挥发机制。最后,将算法应用到不同复杂环境,与已有改进蚁群算法对比分析,研究结果说明改进算法在有效时间、平均距离、最短距离的优越性。
杨俊起刘飞洋张宏伟
关键词:蚁群算法改进蚁群算法全局优化路径规划
基于量子蚁群算法的旅行商问题求解及算法评估
2024年
量子蚁群算法是一种将量子理论与传统蚁群算法结合的高效生物进化算法,主要应用于故障诊断、路径规划、图像分割等问题的优化.基于传统蚁群算法的流程,介绍量子蚁群算法中的量子理论基础以及量子理论如何应用于蚁群算法.通过若干旅行商问题实例分析量子蚁群算法较传统蚁群算法的优势.针对目前研究多以离散指标来评估不同算法、难以直观显示不同算法综合差别的问题,提出一种综合评估算法搜索效率的方法,成功应用于量子蚁群算法和传统蚁群算法的对比,具有一定的实践意义.
李炫秋黄斐君景鹏飞
关键词:量子蚁群算法蚁群算法旅行商问题
巨噬细胞集落刺激因子-1及其受体在牙周炎中的研究进展被引量:1
2024年
牙周炎是一种影响牙齿周围支持组织的慢性炎症性疾病。牙周组织损伤主要由宿主的免疫反应介导,而目前临床治疗牙周炎主要以局部机械清除菌斑和结石为主,免疫疗法在牙周临床中应用很少。因此,对牙周炎免疫治疗的研究就显得极其重要。巨噬细胞参与宿主免疫反应的关键环节,通过识别、吞噬和清除外来病原体和异物在牙周炎的发生、发展过程中发挥重要作用。研究表明,这一过程是通过巨噬细胞集落刺激因子-1(colony stimulation factor-1,CSF-1)/巨噬细胞集落刺激因子-1受体(colony stimulation factor-1 receptor, CSF-lR)信号轴介导的巨噬细胞炎性调控、破骨细胞骨吸收调控进行的。本综述将CSF-1/CSF-1R信号轴在牙周炎中的作用及其作用机制进行总结,以期为后续研究及牙周炎的免疫治疗提供依据。
湛济帆田艾
关键词:巨噬细胞破骨细胞牙周炎
基于林地综合代价地图与开拓优化机制的改进蚁群算法
2024年
针对传统蚁群算法在林业机器人路径规划中未能考虑林区地形与地表状态,且收敛速度慢,易陷入局部最优的问题,提出一种基于林地综合代价地图与开拓优化机制的改进蚁群算法。基于林区地形地表构建林地综合代价地图;在蚁群搜索阶段中引入开拓优化机制;在轮盘赌中引入随机游走机制,并将其应用到林业机器人路径规划问题中。实验表明:改进蚁群算法能搜寻到更佳路径,具有更好的全局寻优能力。
何浩天彭富明方斌相福磊张少杰
关键词:蚁群算法
Colony performance of three native bumblebee species fromSouth China and association with their gut microbiome
2024年
Bumblebees play an important ecological economic role as pollinators in natureand agriculture.For reasons of biosecurity,many countries promote the cultivation of na-tive bumblebee species for crop pollination instead of importing“alien”species.In SouthChina,a few bumblebee species are considered useful in this way,particularly,Bombusatripes,Bombus bicoloratus and Bombus breviceps.However,whether they are suitablefor artificial rearing and forming healthy colonies for pollination,remains unknown.Inthis project,queens from the 3 native species of Guizhou Province were collected andcolonies were started under standardized conditions.The colonies were scored based on19 parameters,including the stage of colony development,number and weight of off-spring,and diet consumed.The data revealed that B.breviceps had the best performance,produced more workers and consumed the smallest diet.Next,we performed 16S rDNAsequencing of the bacterial communities found in the guts of offspring workers,and thena correlation analysis between colony performance and gut bacteria was conducted.Here,B.breviceps showed the highest diversity in gut bacterial composition,dominated by thebacteria Gilliamella,Snodgrassella,Enterobacter,and Lactobacillus Firm5.The higherthe abundance of Snodgrassella,the better the performance of the colony in the founda-tion stage,and later Lactobacillus Firm5,Apibacter and Bifidobacterium were beneficialduring the stages of rapid growth and colony decline.Although we do not understand allof the interactions yet,these correlations explain why B.breviceps demonstrated bettercolony performance.Our data provide valuable information for breeding local Bombusspecies and will contribute to developing strong colonies for crop pollination.
Lei HanZhi-Min ChangChang-Shi RenXiang-Sheng ChenGuy SmaggheYi-Ge YuanJian-Kun Long
平板计数法与测试片法对不同类型食品中菌落总数结果的比较分析
2024年
本文比较了平板计数法、凝胶型菌落总数测试片法和无纺布型菌落总数测试片法对检测不同类型样品中菌落总数结果的差异。通过比较大肠埃希氏菌、金黄色葡萄球菌和枯草芽孢杆菌标准菌株分别在平板计数琼脂、凝胶型菌落总数测试片和无纺布型菌落总数测试片3种培养基中的菌落形态,并采用这3种方法对2种食品样品Y628和A530进行菌落总数测定和数据分析,确保检验结果的准确性。实验结果显示,凝胶型菌落总数测试片在菌落辨识度上优于平板计数琼脂和无纺布型菌落总数测试片,对于不同样品的检测,结果更易于判读和计数。采用凝胶型菌落总数测试片和无纺布型菌落总数测得的结果与平板计数琼脂测得的结果无显著差异。利用传统平板计数法与市面上不同类型的菌落测试片法对样品Y628和A530的菌落总数进行测定,结果并没有显著性差别,因此菌落总数测试片也可作为上述食品的菌落总数测定。
麻晓莉
关键词:菌落总数配对T检验

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李世平
作品数:33被引量:184H指数:9
供职机构:扬州大学生物科学与技术学院
研究主题:细胞色素B基因 多态性研究 基因序列分析 MYOSTATIN基因 遗传分化
王建设
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供职机构:复旦大学附属儿科医院
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常春芳
作品数:25被引量:90H指数:7
供职机构:扬州大学动物科学与技术学院
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何立居
作品数:44被引量:75H指数:5
供职机构:广州航海学院
研究主题:电子海图 船舶 AIS 航海教育 蚁群算法
朱玲玲
作品数:1被引量:0H指数:0
供职机构:格拉斯哥大学
研究主题:LINGUISTIC LANGUAGE CONCENTRIC BRITISH COLONY