近年来,甲状腺癌(TC)的发病率在全球范围内迅速上升,中国城市女性TC的发病率已在所有女性恶性肿瘤中位居第四。肥胖作为一种日益严重的全球性健康问题,它被认为是癌症发病和死亡的一个可预防的危险因素。目前,肥胖和超重已被证实与TC的风险增加有关。然而,临床上肥胖与TC的相关作用机制尚处于探索阶段。脂肪因子作为肥胖细胞分泌物,同时也是肿瘤微环境的重要组成成分,今后的研究可以从脂肪因子途径和慢性炎症反应等途径中寻找肥胖与TC相结合的机制。本综述围绕肥胖与TC的临床相关性,探究两者之间潜在的作用机制,旨在为今后的基础和临床研究提供参考。In recent years, the incidence of thyroid cancer (TC) has risen rapidly worldwide, and the incidence of TC among urban women in China has ranked fourth among all female malignancies. Obesity is a growing global health problem and is considered a preventable risk factor for cancer morbidity and mortality. Currently, obesity and overweight have been shown to be associated with an increased risk of TC. However, the clinical mechanism of obesity and TC is still in the stage of exploration. Adipokine, as a secretion of obesity cells, is also an important component of the tumor microenvironment. Future studies can look for the mechanism of the combination of obesity and TC through adipokine pathway and chronic inflammatory response. This review focuses on the clinical correlation between obesity and TC and explores the potential mechanism of action between the two, aiming to provide reference for future basic and clinical research.
