2型糖尿病是一种发病机制复杂,以胰岛素抵抗、β细胞数量减少与功能障碍为特征的疾病,糖尿病肾脏病(Diabetes Kidney Disease, DKD)是糖尿病常见的慢性并发症之一,是由糖尿病引起的慢性肾脏病(CKD)。近年来,一些研究表明,miRNA451a与胰岛素抵抗存在一定关系,在糖肾中发生表达的改变,影响糖肾的进展。本文综述了胰岛素抵抗和糖肾的发病机制与miRNA451a的关系,为更深入地了解miRNA51a对2型糖尿病及糖肾的发病机制及治疗提供参考。Type 2 diabetes is a complex disease characterized by insulin resistance, reduced β-cells and its dysfunction. Diabetic kidney disease (DKD) is one of the common chronic complications of diabetes and is chronic kidney disease (CKD) caused by diabetes. In recent years, several studies have shown that a certain relationship between miRNA451a and insulin resistance, and its altered expression occurs in DKD, affecting the progression of DKD. This review summarizes the relationship between insulin resistance and DKD with miRNA451a to provide a further understanding of the pathogenesis and treatment of miRNA51a in type 2 diabetes and DKD.
目的:DEXA测量成人体脂质量分数及分布,分析体脂质量分数与胰岛素抵抗、胰岛β细胞功能及代谢紊乱的关系,揭示体脂与2型糖尿病及心血管的相关性.方法:2型糖尿病(n=44)及非糖尿病(n=21)患者,记录血液生化指标、DEXA测定全身脂肪质量分数及分布、冠脉CT等临床资料并检测基线观察指标.结果:糖尿病与非糖尿病患者舒张压、餐后2 h血糖、餐后2 h C肽、HbA1c、BMI、HOMA-β、体脂质量分数等指标有统计学差异(P<0.05);冠状动脉钙化积分主要影响因素:TC(β=25.753,P<0.01),HDL-C(β=-32.954,P<0.01),HbA1c(β=3.34,P=0.02):HOMA-IR主要影响因素:LDL-c(β=0.719,P=0.03),BMI(β=2.619,P<0.01):HOMA-β主要影响因素:LDL-c(β=78.934,P<0.01),躯干脂肪含量(β=3.87,P=0.02).结论:体脂质量分数和分布影响胰岛细胞功能、心血管系统.
