Objective To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods By searching journal literature on chronic gastritis treated with acupuncture and moxibustion in recent 10 years,with data mining,the acupoints screened from literature were analyzed.Results A total of 803 articles were included finally.Conception vessel,stomach meridian and bladder meridian were mostly selected,the acupoints were selected from the abdomen,the thigh/crus,the back and the arms.The top 5 aucpoints with high frequency were Zúsānǐ(足三里ST36),Zhōngwǎn(中脘CV12),Wèishū(胃俞BL21)(332),Píshū(脾俞BL20)and Nèiguān(内关PC6).The top 5 acupoint combinations with high frequency included CV12 combined with ST36,BL21 with CV12,BL21 with ST35 and BL20 with CV12.The mostly used specific points were front-mu point,he-sea point,crossing point and back-shu point.Conclusion In treatment of chronic gastritis with acupuncture and moxibustion,conception vessel,stomach meridian and bladder meridian are particularly selected in combination and the specific points with duplicate effect are mostly selected,especially focusing on the application of front-mu point.
目的探讨补肾活血方抑制卵巢早衰(POF)小鼠卵泡颗粒细胞凋亡的作用机制。方法以小鼠透明带3为抗原,皮下多点注射免疫BALB/c雌性小鼠建立免疫性POF模型。取40只清洁级雌性小鼠,随机分为空白组、模型组、阳性药组、补肾活血方组。补肾活血方组给予补肾活血方药液灌胃,阳性药组给予戊酸雌二醇药液灌胃,模型组和空白组给予等量生理盐水灌胃,2次/d,连续15 d。取卵巢、子宫、胸腺进行称重,计算其脏器指数;HE染色观察颗粒细胞凋亡情况;采用放射免疫法检测雌二醇(E2)、促黄体生成激素(LH)和促卵泡生成激素(FSH)的水平;采用RT-PCR分析卵巢颗粒细胞中Fas、Fas-L m RNA表达情况。结果与空白组比较,模型组卵巢、胸腺、子宫质量和E2水平显著降低(P<0.05,P<0.01),FSH、LH水平和Fas、Fas-L m RNA表达显著升高(P<0.01);与模型组比较,给药组颗粒细胞凋亡明显减少,卵巢指数、子宫指数、胸腺指数增加(P<0.05),E2水平升高(P<0.01),FSH、LH水平及Fas、Fas-L m RNA表达明显降低(P<0.05,P<0.01)。结论补肾活血方可调节下丘脑-垂体-卵巢轴的激素水平,通过降低Fas、Fas-L的m RNA表达抑制细胞凋亡。
