A novel modified electrode for the voltammetric determination of acetaminophen has been fabricated based on electropolymerization of L-serine on a glasy carbon electrode.Voltammetric behaviour of acetminophen on the modified electrode was investigated by cyclic voltammetry and linear sweep voltammetry.It was found that the oxidation peak current of acetaminophen was enhanced greatly on the modified electrode.A linearity between the oxidation peak current and the acetaminophen concentration was obtained in the range of 1.00×10-7-2.00×10-5 mol L-1 with a detction limit of 7.00×10-8 mol L-1.The practical application of the modified electrode in the determination of acetaminophen in a paracetamol oral solution demonstrated it has good selectivity and high sensitivity.
