Cyproconazole(5) is a good fungicide.In this paper,starting from p-chlorobenzonitrile and allylic bromide,the intermediate 1-(4-chlorophenyl)-2-cyclopropyl-1-ethanone(2) was obtained by Barbier-type reaction and Simmons-Smith reaction.The product 5 was synthesized form 2 via α-methyl reaction,Corey-Chaykovsky reaction,and substitution reaction with 1,2,4-triazole.The total yield was 30.8%.5 and all intermediates were characterized and confirmed with 1H NMR and MS spectra.This procedure was cost-effective and applicable on a multigram scale.
