失眠是一种常见的临床疾病,表现为入睡困难,早醒,睡眠时间短甚至彻夜不眠,严重影响患者生活质量。临床上常将其分为原发性失眠和继发性失眠两大类。近年来,失眠的机制已被证实与脑神经有关,但其潜在的内分泌机制尚不清楚。本文基于目前国内外失眠的神经–内分泌–免疫机制的前沿进展,从调节神经递质、调节内分泌激素、调节免疫细胞因子等方面入手,对失眠的内分泌机制进行论述,归纳治疗失眠的中医常见临床方法与内分泌机制的潜在联系,总结中医治疗失眠的独特优势。Insomnia is a common clinical disease, manifested as difficulty in falling asleep, early awakening, short sleep time or even sleepless nights, which seriously affects the quality of life of patients. Clinically, it is often categorized into two main types: primary insomnia and secondary insomnia. In recent years, the mechanism of insomnia has been proved to be related to the brain nerves, but its underlying endocrine mechanism is still unclear. Based on the frontier progress of the neuro-endocrine-immune mechanism of insomnia at home and abroad, this paper discusses the endocrine mechanism of insomnia from the aspects of regulating neurotransmitters, regulating endocrine hormones and regulating immune cytokines, summarizes the potential connection between common clinical methods of Chinese medicine for treating insomnia and the endocrine mechanism, and concludes the unique advantages of Chinese medicine in treating insomnia.
甲状腺结节作为常见的内分泌疾病,它的发生和发展机制是复杂的,纵横交错,与胰岛素抵抗、饮食中碘摄入异常、内分泌失调、炎症因子、细胞凋亡异常、细胞因子失衡有关,还与遗传、物理刺激、性别、吸烟等因素有关。但对于其致病机制的研究仍不充分。目前西医对于甲状腺结节的治疗手段丰富,但其治疗效果并不令人满意。甲状腺结节的出现对患者的生活质量影响非常严重,因此对甲状腺结节的发病机制进行深入研究,寻找有效的治疗手段尤为必要。As a common endocrine disease, thyroid nodules have a complex and criss-crossing mechanism of occurrence and development, which is related to insulin resistance, abnormal iodine intake in diet, endocrine disorders, inflammatory factors, abnormal apoptosis, cytokine imbalance, and also related to genetics, physical stimulation, gender, smoking and other factors. However, the mechanism of pathogenesis is still insufficient. At present, Western medicine has a variety of treatment methods for thyroid nodules, but the treatment effect is not satisfactory. The appearance of thyroid nodules has a very serious impact on the quality of life of patients, so it is particularly necessary to conduct in-depth research on the pathogenesis of thyroid nodules and find effective treatment methods.
