[Objective] To extract desertification information of Hulun Buir region based on MODIS image data. [Method] Based on MODIS image data with the spatial res- olution of 1 km, 5 indicators which could reflect different desertification features were selected to conduct inversion. The desertification information of Hulun Buir region was extracted by decision tree classification. [Result] The desertification area of Hu- lun Buir region is 33 862 km2, accounting for 24% of the total area, and it is mainly dominated by sandiness desertification. Though field verification and mining point validation of high-resolution interpretation data, the overall accuracy of this evaluation is above 89%. [Conclusion] Evaluation method used in this study is not only effectively for large scale regional desertification monitoring but also has a better evaluation performance.