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陈瑞琴

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供职机构:北京师范大学化学学院放射性药物教育部重点实验室更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划更多>>
相关领域:医药卫生更多>>

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Bio-distributions of [^(125)I]Spiro-I liposomes in mice
2010年
We investigated the bio-distributions of [125 I]Spiro-I formulated in sterically stabilized liposomes (SSL) or targeted liposomes (SSTL) in mice,especially their brain uptake.The [125 I]Spiro-I liposomes were prepared by film-ultrasound dispersion method.Cereport (RMP-7) was covalently conjugated with DSPE-PEG,which was attached to the surface of SSL to form SSTL.The encapsulation efficiencies (ee%) of [125 I]Spiro-I-SSL and [125 I]Spiro-I-SSTL were 97.47%±4.01% and 93.02%±2.98%,respectively.The average particle sizes were (66.47±0.76) nm and (71.40±0.45) nm,respectively.After intravenous administration,[125 I]Spiro-I was quickly eliminated from blood.SSL could prolong the retention time of [125 I]Spiro-I in blood and SSTL improved its brain uptake.The AUC of [125 I]Spiro-I-SSTL in brain was increased by 1.52 times as compared to [125 I]Spiro-I,indicating that SSTL could be used for the formulation of [125 I]Spiro-I for the imaging of central nervous system (CNS).
周鹤翔陈瑞琴孙慧张沛然贾红梅谢英
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