炎症性疾病(inflammation disease, ID)是泛指一类伴有炎症反应的一系列疾病,其发病机制复杂。环状RNA (circular RNA, circRNA)是一类经过反向剪接形成的具有闭合环状结构的、大量存在于真核转录组中的非编码RNA,是目前生命科学和医学领域研究的热点分子,其在不同疾病中呈差异性表达,参与机体各类生理和病理过程。本文将对环状RNA在肿瘤、心血管疾病、神经系统疾病、糖尿病、自身免疫性疾病及感染性疾病等ID中的最新研究进展进行综述,以期为环状RNA在基础和临床的研究提供参考。Inflammatory Disease refers to a series of diseases accompanied by inflammatory reactions, and its pathogenesis is complex. Circle RNA is a kind of non-coding RNA with closed ring structure formed by reverse splicing, which exists in a large number of eukaryotic transcriptome. It is a hot molecule in the field of life science and medicine. Studies have found that it is differentially expressed in different diseases and participates in various physiological and pathological processes. In this review, we will review the recent research progress of circRNAs in inflammatory diseases of cancer, cardiovascular disease, neurological disease, diabetes, autoimmune diseases and infectious diseases. In order to provide theoretical basis for circrnas in clinical and basic research.
目的:探讨降钙素原与白蛋白比值(PAR)在脓毒症并发急性呼吸窘迫综合征(ARDS)预后中的评估价值。方法:回顾性分析2019年9月~2022年9月入住益阳市中心医院呼吸内科重症监护室(Respiratory Intensive Care Unit, RICU)的131例脓毒症并发ARDS患者的临床资料,根据患者28天预后,进一步将脓毒症并发ARDS患者分成生存组(n = 71)和死亡组(n = 60),比较两组降钙素原与白蛋白比值的差异,采用受试者工作曲线(ROC)评估PAR对脓毒症并发ARDS的预后价值;Spearman相关分析分析PAR与SOFA评分的相关性;Cox回归筛选脓毒症并发ARDS预后的独立危险因素;进一步比较不同亚组的PAR水平;最后采用Kaplan-Meier生存分析法比较不同PAR水平患者的生存率。结果:死亡组PAR水平显著高于生存组[0.85 (0.11, 2.84) vs. 0.19 (0.03, 1.01), P = 0.001]。ROC曲线分析表明,PAR判断脓毒症并发ARDS的预后性能最佳,曲线下面积(AUC)为0.725 (95% CI: 0.6141~0.800, P 1.74的脓毒症并发ARDS患者28-d预后更差(P 1.74时,脓毒症并发ARDS患者28 d死亡率更高。
