[Objective] The research aimed to assess the water resources carrying capacity in Guizhou Province based on the cosine vector included angle method. [Method] By using the cosine vector included angle method, the index weight was determined. The projection value of water resources carrying capacity in Guizhou Province was counted by using the multi-objective gray relational projection method. Moreover, the projection value which was counted by the index weight determined by the mean-variance method was as the control. [Result] The projection values which were obtained by two kinds of methods were very close, and the ordering result was consistent. [Conclusion] In the assessment of water resources carrying capacity, it was feasible to use the cosine vector included angle method to determine the index weight.