目的 比较慢性丙型肝炎患者接受聚乙二醇干扰素α( peg ifnα) -2a或peg ifnα-2b联合利巴韦林治疗后的疗效差异.方法 对46例慢性丙型肝炎(chc)患者进行回顾性分析,将患者分为2组,peg ifnα-2a组24例,每周1次皮下注射peg ifnα-2a 180μg,peg ifnα-2b组22例,1.5 μg ·kg-1·周-1,2组均l司时服用利巴韦林.在治疗的第4、12和24周检测患者血清hcv rna载量评估病毒学应答情况.采用spss13.0和pems3.1软件进行分析.结果 两组患者治疗后快速病毒学应答、早期病毒学应答、完全应答和无应答率差异无统计学意义(x2=0.689、0.105、0.105和0.105,p＜0.05).基线hcv rna ＞6 logl0拷贝/ml的患者中,使用peg ifnα-2a治疗的快速病毒学应答率为86.67％,高于使用peg ifnα-2b治疗的快速病毒学应答率(42.86％)(x2=4.365,p＜0.05).结论 peg ifnα-2a联合利巴韦林治疗慢性丙型肝炎的快速病毒学应答率优于peg ifnα-2b.abstract：objective to compare the virological responses between peg ifnαt-2a and peg ifnα-2b in treatment of chronic hepatitis c.methods clinical data of 46 chronic hepatitis c (chc) patients were retrospectively reviewed.patients were divided into two groups:peg ifnα-2a group ( n =24) was given peg ifnoα-2a 180 μg/week and ribavirin; peg ifnα-2b group (n =22 ) was given peg ifnα-2b1.5 μg · kg-1 · week-1 and ribavirin.serum hcv rna load at 4th,12th and 24th week of the treatment were detected to evaluate the virological responses.softwares spss 13.0 and pems 3.1 were used for statistical analysis.results there was no significant difference in rapid response rate,early response rate,complete response rate and non-response rate between the two groups (x2 =0.689,0.105,0.105 and 0.105,p ＞ 0.05 ).however for patients with high viral load ( hcv rna ＞ 6 logl0 copies/ml) at baseline,the rapid response rate in peg ifnα-2a group ( 86.67％ ) was higher than that in peg ifnα-2bgroup (42.86％ ) (x2 =4.365,p ＜ 0.05 ).conclusion peg ifnα-2a combined with
