Objective To study the roles Of VEGF,No and lymphcyte slL-2R in theonsert of ovarian hyper-stimulation syndromeOHSS) with combined determination of these factors in the liquor folliculi and plasma of OHSS patients.Methods The liquoufolliculi,blood sample of the day Of ovum-takingS1),and blood sample of the seventh dayafter ovum-takingS7) of 12 cases of moderate to severe OHSS patientsOHSS group) and 26 cases of patients without OHSScontrol group)were collected in the period of ⅣF—ET And the levels of VEGF,NO and lymphcyte slL-2R were determined to observe their regular rule of change.Results The levels Of VEGFand lymphcyte slL-2R in the liquor follichli and S1 of the OHSS group were not significantly different from those of the control groupP>0.05),but the level of NO was significantly different that of the control,groupP>0.01).The levels Of VEGF,NO and lymphcyte sIL-2R in S7 were significantly different from those of the control groupP<0.01).Conclusion VEGF may take part in the onset of OHSS.The increase of the expression of lymphcyte sIL-2R indicates the participation of immune factors in the process of onset.As excessive NO in OHSS patients exerts pathologic action,its cytotoxic effect stimulates immunocytes to realease inflammatory cell factor,which further increase the expression of VEGF and worsens the patient’s,condition.It is simple to monitor the level of NO and lymphcyte sIL-2R in blood samples.
