在临床实践中,诊断和预后评估通常依赖多种实验室和评分指标。近年来,红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)和红细胞分布宽度与血小板计数比值(RPR)作为新兴复合实验室指标,在疾病诊断和预后评估中展现出显著价值。尤其是在急性疾病中,这些指标因其快速获得的特性而备受关注。文章综述了RDW和RPR在脑卒中、急性心肌梗死、冠状动脉介入治疗、脓毒症及恶性肿瘤中的最新研究进展,强调其在预测疾病严重程度和预后中的潜力。研究表明,RDW和RPR作为早期获取的指标,能够有效评估上述疾病患者的病情演变和预后。其进一步研究有望推动这些指标在临床中的广泛应用。In clinical practice, diagnosis and prognosis assessment often rely on various laboratory and scoring indices. In recent years, emerging composite laboratory indices such as red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and the ratio of red blood cell distribution width to platelet count (RPR) have demonstrated significant value in disease diagnosis and prognosis evaluation. Particularly in acute diseases, these indices have gained attention due to their rapid availability. This review summarizes the latest research on RDW and RPR in conditions such as stroke, acute myocardial infarction, coronary artery interventions, sepsis, and malignancies, highlighting their potential in predicting disease severity and outcomes. Studies indicate that RDW and RPR, as early accessible markers, can effectively evaluate disease progression and prognosis in these patients. Further research is expected to promote the widespread clinical application of these indices.