With small somatotype, gentle temperament, balanced hematological and blood biochemical index, Beagle was ideal for laboratory use. Since 1980, beagle has been introducted into our country. They were successfully bred and multiplied in Guangdong , Shanghai and Beijing . But the control of heredity, balance of gene frequency, gene diversity and gene differentiation and protection of idioplasm has not been well studied. Falk & Holsinger(1991)point out: we can not protect what were unknowed. For operative preventing the inbreeding diminution , gene segregation and differentiation, the DFP and randomly amplified polymorphic (RAPD) technique were applied to assess the genetic variation and colony heredity structural analysis among the population of three internal beagle centers and Marshell beagle in America. The experimental exponent of the heredity analysis in different colony were from Guangdong, Shanghai, Beijing and Marshell (Amereca), and they were not relative. The experimental exponent of the different generation were from Beijing colony, and they were direct maternal side in different generation, but each individual were no relative in the same generation. The heredity structive relatio on different colony and internal colony were analyzed with Phyltools6.0 and SAS6.12 software. The dendrogram of UPGMA based on Nei’s genetic identity of four colony wre constructed. The result showed: There were average distinguished bands 9.8±1.789 in America colony, 10.2±0.837 in Guangdong colony, 10 8±1 483 in Shanghai colony,11.2±2.280 in Beijing colony,and there were 10.5 average bands in the four colonies. The bands owned by both were 0.204 in America colony, 0.294 in Guangdong colony, 0.370 in Shanghai and 0.267 in Beijing respectively. The similarity coefficient were 0.508—0.557(average 0.526). there were no marked difference in the four different area colony. The dendrogram of UPGMA based on Nei’s genetic distance coefficient was drawn: the gene distance of colony between Guangdong and Shanghai was close, an
