Human hepatoma and normal liver cells were irradiated with 12C6+ ion beams (LET = 96.05 keV/μm) and γ-rays at Heavy Ion Research Facility in Lanzhou (HIRFL). The chromatid breaks and break types were detected using the premature chromosome con- densation technique. Our experimental results showed that chromatid breaks seem to have a good relation with 12C6+ absorbed dose and 12C6+ are more effective to induce chromatid breaks as compared to the γ-rays. For 12C6+ ion irradiation the major break was isochromatid break, while chromatid breaks were dominant for γ-ray irradiation. We also observed that the Relative Biology Effectiveness (RBE) of 12C6+ ion is about 2.5 times higher than that of γ-rays.
YANG Jianshe1,2, LI Wenjian1, JIN Xiaodong1, JING Xigang1, GUO Chuanling1, WEI Wei1 & GAO Qingxiang3 1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
