Two new complexes （Cp）2Ti（Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（m-chloro-phe- nyl） anthranili acid, acidum clofenamicum] with （Cp）2 TiCl2 and characterized by means of elemental analyses, IR, 1 H NMR, 13 C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or （Cp）2 Ti（Clo）2 , the oxygen atom of the carboxyl group coordinates to Ti（IV） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [（Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.
在乙醇中以乙酸稀土或在无水乙醇中以无水氯化钕与二甲双胍(以DMBG表示)反应,合成了二甲双胍乙酸钕、钐和二甲双胍氯化钕3种固态配合物。元素分析、ICP、IR、UV、荧光光谱等测试技术研究表明,配合物的化学组成分别为Re(DMBG)2(CH3COO)3(Re=Nd(Ⅲ),Sm(Ⅲ)离子,CH3COO-为乙酸根)和Nd(DMBG)2(EtO)C l2(EtO为乙氧基阴离子)。通过糖尿病小鼠模型观察了它们的降血糖作用,通过ESR谱测定了对人工脂质体膜超氧自由基的清除率。实验结果表明,二甲双胍乙酸钕[Nd(DMBG)2(CH3COO)3]的降血糖作用和对超氧离子自由基的清除率均高于盐酸二甲双胍(M etform in,D im ethylb iguam ide hydrochloride简称DMBG.HC l),表明其降血糖作用与其抗氧化作用或对细胞膜的保护作用具有相关性。
