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国家自然科学基金(81201824)

作品数:3 被引量:7H指数:2
相关作者:雷建军仵正王铮徐军马清涌更多>>
相关机构:西安交通大学医学院第一附属医院更多>>
发文基金:国家自然科学基金中央高校基本科研业务费专项资金国家教育部博士点基金更多>>
相关领域:医药卫生更多>>

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连续贯穿端侧胰肠吻合术的临床观察被引量:4
2016年
胰瘘是众多外科医师公认的胰十二指肠术后最难处理的严重并发症之一。据文献报道,胰瘘的发生率为5%~30%,是胰十二指肠手术病死率较高的重要原因。胰腺断端的吻合方式主要有两种:胰肠吻合和胰胃吻合。据文献报道,两种吻合方式之间胰瘘的发生率无差异,胰肠端端及端侧吻合之间胰瘘的发生率亦无差异。
王铮雷建军徐军马清涌仵正
关键词:胰肠吻合术端侧吻合严重并发症发生率外科医师
Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer
2013年
The CXCR4 and Nrf2 signaling pathways are abnormally activated in response to cellular stress in various types of human cancers. In this study, we examined the expression of CXCR4 and Nrf2 in colorectal cancer (CRC) tissue specimens and investigated their correlation with patient clinicopathologic characteristics. We determined CXCR4 and Nrf2 expression in 76 CRC tissue specimens and paired normal tissue specimens by immunohistochemistry and real-time PCR. We found that the protein and mRNA transcript levels of CXCR4 were significantly higher in CRC tissue specimens than in paired normal tissues, while the expressions of Nrf2 protein and mRNA were increased in CRC tissues compared to distant non-cancerous tissues. High expression level of CXCR4 was positively correlated with poorly differentiated (P=0.031), more advanced tumor-node-metastasis (TNM) stage (P=0.019), lymph node metastasis (P=0.007) and distant metastasis (P=0.018). However, the expression of Nrf2 protein was positively correlated with larger tumor size (P=0.049), more advanced TNM stage (P=0.013), lymph node metastasis (P=0.016) and distant metastasis (P=0.023). Moreover, there was a strong relationship between CXCR4 and Nrf2 expression in CRC tissues, indicating that high Nrf2 expression may contribute to CXCR4 overexpression. In addition, combined expression of CXCR4 and Nrf2 strongly correlated with lymph node metastasis and distant metastasis (P=0.003). Furthermore, we found that combined high expression of CXCR4 and Nrf2 had stronger correlation with lymph node metastasis and distant metastasis than any single molecule did. This study indicated that the abnormal expression of CXCR4 and Nrf2 contributed to the progression of CRC.
Tinghua HuYu YaoShuo YuHui GuoLili HanWenjuan WangTao TianYibin HaoZhiyan LiuKejun NanShuhong Wang
关键词:CXCR4NRF2BIOMARKER
Gli-1在缺氧诱导乳腺癌MDA-MB-231细胞上皮-间质转分化中的重要作用被引量:3
2014年
目的探讨Gli-1在缺氧诱导乳腺癌MDA-MB-231细胞上皮-间质转分化(EMT)及侵袭中的重要作用。方法通过缺氧培养乳腺癌MDA-MB-231细胞,以常氧培养作为对照。Transwell小室侵袭试验检测各组MDAMB-231细胞的侵袭能力;Western blot检测HIF-1α、Gli-1、E-Cadherin和vimentin蛋白的表达水平。通过shRNA稳定转染乳腺癌细胞,再次通过Transwell小室侵袭试验检测缺氧对乳腺癌细胞侵袭能力的影响,Western blot检测HIF-1α、Gli-1、E-Cadherin和vimentin蛋白的表达水平。结果缺氧可明显诱导乳腺癌MDA-MB-231细胞侵袭,并上调HIF-1α、Gli-1和vimentin蛋白,下调E-cadherin蛋白。靶向沉默Gli-1基因后,缺氧失去了对乳腺癌细胞侵袭和EMT的诱导作用。结论缺氧通过上调Gli-1表达活化Hedgehog通路,诱导乳腺癌细胞侵袭及EMT过程。
李徐奇雷建军徐勤鸿段万星盛薇王康魏光兵
关键词:乳腺癌缺氧HEDGEHOG通路
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