An investigation was conducted using ^(45)Ca as a radioactive tracer to evaluate calcium antagonistic effects of several extracts from Bambusa Rigida in living rats.The relationship between the flavonoid and saccharide contents of Bambusa Rigida and calcium antagonistic effects were also analyzed.The protective effects of the alkali extracts of Bambusa Rigida on myocardial ischemia were investigated in living rats.The results indicated that the alkali extracts of Bambusa Rigida had a prominent influence on Ca^(2+) influx and efflux in the isolated rat aorta and heart,as they could obviously block ^(45)Ca entering into cells and stimulate efflux of intracellular Ca^(2+).Moreover,the alkali extracts of Bambusa Rigida had favorable protective effects on myocardial ischemia induced either by isoproterenoi injection (ISO) or by the ligation of coronary artery.These results implied that the Bambusa Rigida had attractive potential for the treatment of heart,cerebrovascular and other diseases.However,the conclusion that whether the flavonoid or saccharide in Bambusa Rigida affected the calcium antagonistic effects and Ca^(2+) channels or not was hard to make within the results of the investigation.
LIN Rushan YE Ling YANG Yuanyou LIAO Jiali MO Shangwu LIU Ning
