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国家自然科学基金(30572176)

作品数:13 被引量:9H指数:2
相关作者:方琦陈忠诸葛正兵金春雷更多>>
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13 条 记 录,以下是 1-10
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杏仁核电点燃癫痫对大鼠穿梭箱被动回避反应的记忆保持能力的作用被引量:5
2008年
目的:探讨杏仁核电点燃癫痫对大鼠穿梭箱被动回避反应的记忆保持能力的影响。方法:大鼠每24h进行一次电刺激直至完全点燃,然后利用穿梭箱系统检测慢性电点燃癫痫对大鼠被动回避反应的记忆保持能力的作用;另一组动物于训练前5min给予杏仁核电刺激诱发癫痫大发作,观察癫痫的急性发作对记忆保持能力的作用。结果:在被动回避反应训练过程以及测试第1天,慢性点燃癫痫组和对照组动物进入暗箱的反应潜时没有明显差异;在测试第5天,慢性点燃癫痫组动物进入暗箱的反应潜时比对照组动物明显增加。另外,癫痫的急性发作使大鼠在测试第1天和第5天进入暗箱的反应潜时明显缩短。结论:慢性杏仁核电点燃癫痫可使大鼠被动回避反应的记忆保持能力增加,而癫痫的急性发作减弱了大鼠的记忆保持能力。
诸葛正兵方琦金春雷陈忠
关键词:癫痫杏仁核
Unilateral low-frequency stimulation of central piriform cortex has inhibitory effect on amygdaloid-kindled seizures in rats
Aim: The piriform cortex (PC) is considered to be critically involved in the genesis of lirabic seizures. In t...
Zhu - Ge Zheng - Bing Zhu Yuan - Yuan Wu Deng - Chang Wang Shuang Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058
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Protective effect of carnosine against NMDA-induced neurotoxicity in differentiated rat PC12 cells
Aim: To investigat the neuroprolective effects of carnosine and its mechanisms of action in an in vitro model ...
Shen Yao Fan Yan - Yin Fan Xiao - Ning Dai Hai - Bin, Fu Qiu - Li Hu Wei - Wei Hu Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058
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Lesion of the tuberonianunillary nucleus attenuates postictal seizure protection in rats
<正> To determine whether the tuberomammillary nucleus (TM) is involved in postictal seizure protection (PSP) i...
Li Qing,Jin Chun-lei,Zhuge Zheng-bing,Zhu Yuan-Yuan,Wang Jue,Chen Zhong.Department of Pharmacology.School of Medicine.Zhejiang University.310031
关键词:EPILEPSYHISTAMINE
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Histamine H3 receptor antagonist clobenpropit enhaces GABA release to protect against NMDA -induced excitotoxicity in cultured cortical neurons through the cAMP/PKA pathway
2006年
Dai Hai-BinFu Qiu-LiShen YaoChen Zhong
关键词:CLOBENPROPIT皮质神经元
Protective effect of carnosine against NMDA -induced neurotoxicity in differentiated rat PC12 cells被引量:1
2006年
Shen Yao Fan Yan -Yin Fan Xiao -Ning Dai Hai- Bin Fu Qiu-Li Hu Wei-Wei Hu ChenZhong
关键词:肌肽
Mast cell-derived mediators protects PC12 cells against ischemia in vitro
We have previously demonstrated that brain mast cells degranulated under ischemia in in vivo or in vitro exper...
Fan Yan - Yi Shen Yao Fu Qiu - Li Dai Hai - Bin Hu Wei - Wei Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China, 310058
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Protective effect of carnosine on amyloid - β42 - induced neurotoxicity in differentiated rat PC12 cells is independent of histamine pathway
2006年
Fu Qiu-Li Dai Hai-Bin Shen Yao Hu Wei-wei Chen Zhong
Low-frequency stimulation of histaminergic tuberomammillary nucleus facilitates basolateral amygdaloid kindling in rats
Aim: The tuberomammillaiy nucleus ( TM) , located in the posterior hypothalamus, is the sole seat of histamine...
Zhu - Ge Zheng - Bing Wu Deng - Chang Wang Shuang Jin Chun - Lei Chen Zhong Department of Pharmacology, School of Medicine, Zhejiang University Hangzhou 310058
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The role of carnosine-histidine-histamine pathway in the CNS
<正>Epilepsy is one of the most common neurological disorders and characterized by recurrent seizures,afflictin...
Yao SHEN,Wei-Wei HU,Chun-Lei JIN,Shi-Hong ZHANG,Zhong CHEN~* Department of Pharmacology,Institute of Neuroscience,School of Medicine,Zhejiang University,Hangzhou 310058, China
关键词:HISTAMINE
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