国家自然科学基金(30660225)
- 作品数：1 被引量：6H指数：1
- 相关作者：金泉廉丽花南极星更多>>
- 相关机构：延边大学更多>>
- 发文基金：国家自然科学基金更多>>
- 相关领域：医药卫生更多>>
- Effects of YC-1 on apoptosis of hepatic stellate cells
- OBJECTIVE To study the effects and mechanisms of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole(YC-1) ...
- OUYANG Bing-qingWU Yan-lingNAN Ji-xing
- 关键词：YC-1APOPTOSISHEPATICCELLSΑ-SMA
- 25-OCH3-PPD triggers anti-fibrosis activity via c-FLIP-mediated NF-κB activation on activated t-HSC/Cl-6 cells
- 25-OCH3-PPD is a dammarane-type triterpene sapogenin isolated from the roots, leaves and seeds of P.notoginsen...
- WU Yan-lingWAN YingOUYANG Bing-qingBAITingNAN Ji-xing
- 关键词：ANTI-FIBROSISC-FLIPNF-ΚB
- Thymoquinone down-regulation lipopolysaccharide-induced TLR4 signaling via suppressing nuclear factor-κB activation in hepatic stellate cells
- OBJECTIVE Thymoquinone (TQ) is the major active compound derived from the medicinal Nigella sativa.It has been...
- BAI TingWU Yan-lingLIAN Li-huaNAN Ji-xing
- 关键词：THYMOQUINONEHEPATIC
- Betulinic acid exerts anti-fibrosis activity via regulating TLR4/NF-κB signaling and induces the apoptosis of activated hepatic stellate cells
- OBJECTIVE The purpose of the study was to investigate the anti-fibrosis mechanism of betulinic acid (BA), an a...
- WAN YingNAN Ji-xingWU Yan-lingLIAN Li-huaXIE Wen-xueLI XinOUYANG Bing-qingBAI TingLI QianYANG Ning
- 关键词：HSC-T6HEPATICFIBROSISTHIOACETAMIDE
- 翻白草诱导人肝癌细胞HepG-2凋亡的研究(英文)被引量：6
- 2011年
- 目的:研究翻白草乙醇提取物对人肝癌细胞HepG-2体外增殖的抑制作用及凋亡的诱导作用。方法:用不同浓度的翻白草乙醇提取物对人肝癌细胞HepG-2,MTT法测定对细胞生长的抑制率,用琼脂糖凝胶电泳观察DNA梯状条带和DAPI染色观察凋亡小体,再用Western blot法检测对caspase-3和PARP蛋白表达的影响。结果:翻白草乙醇提取物对人肝癌细胞HepG-2有较强的浓度依赖性抑制作用,诱导细胞出现明显的形态学改变,琼脂糖凝胶电泳出现典型的DNA梯状条带,Western blot分析结果发现,翻白草乙醇提取物促进caspase-3活化而引发下游PARP裂解,进而诱导人肝癌细胞HepG-2细胞走向自体凋亡的途径。结论:翻白草乙醇提取物可能通过抑制人肝癌细胞HepG-2的增殖及诱导其凋亡而产生抗肿瘤作用。
- 金泉南极星廉丽花
- 关键词：翻白草HEPG-2细胞抗肿瘤细胞凋亡
