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国家自然科学基金(10574046)

作品数:14 被引量:18H指数:3
相关作者:孙真荣王祖赓张向韵张诗按蔡炜颖更多>>
相关机构:华东师范大学教育部华东理工大学更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划教育部“新世纪优秀人才支持计划”更多>>
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14 条 记 录,以下是 1-10
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甲醇溶液相干反斯托克斯拉曼光谱(CARS)的选择激发
2008年
利用飞秒自适应脉冲整形相干控制技术成功实现了甲醇溶液中甲基对称(v_S(CH_3)2832 cm^(-1))和反对称(v_(AS_(CH_3)2948cm^(-1))振动能级相干反斯托克斯拉曼光谱(CARS)的选择激发。为了进一步探究双光束飞秒CARS光谱实现选择激发的机制,采用二次谐波频率分辨光学开关(SHG-FROG)测量方法对整形前后的泵浦激光脉冲进行了探测。SHG-FROG痕迹结果显示裁剪泵浦光中的有效频段可实现飞秒CARS的选择激发。研究表明飞秒自适应脉冲整形相干控制技术对于复杂分子系统飞秒CARS的选择激发研究具有非常重要的科学意义。
李霞张晖张诗按张向韵陈果良王祖赓孙真荣
关键词:量子相干控制遗传算法
Linear and third-order nonlinear optical properties for the heptamethine cyanine chromophore H-aggregates thin film
2007年
The thin film of a heptamethine cyanine chromophore HC was prepared by spin-coating technique. Its surface morphology and linear optical property were characterized by atomic force microscopy (AFM) and UV-visible absorption spectroscopy. The results show that HC molecules are arranged in a well-ordered H-aggregate type. The third-order nonlinear optical properties of the spin-coating film were also measured by degenerate four-wave mixing (DFWM) measurement. Enhanced third-order nonlinear susceptibility can be attributed to molecular aggregation effects, and the corresponding mechanism was dealt with by collective electronic oscillator (CEO) approach.
YUAN YiZhongKANG HaiFengSUN ZhenRongWANG ZuGeng
关键词:非线性光学发色团
Dependence of surface-enhanced Raman scattering from Calf thymus DNA on anions被引量:4
2008年
Dependence of surface-enhanced Raman scattering (SERS) from Calf thymus DNA on anions is investigated. With the silver colloid, the bands at 732, 960 and 1333 cm^-1 for adenine (A), 1466 cm^-1 for deoxyribose, and 1652 cm^-1 for the C=O group of thymine (T) are observably enhanced. With the presence of the Cl^- or SO4^2- anions, the bands at 732 and 1326/1329 cm^-1 for the symmetric stretching and skeletal vibrational modes of adenine (A) are dramatically enhanced, and the enhancement effect with the SO4^2- ion is more than that with the Cl^- ion. The experimental results show that the DNA molecule can be adsorbed on the silver colloid particles through the C6N and N7 of adenine (A) the C=O of thymine (T) and deoxyribose. Moreover, the formed hydrogen bonding of the Cl^- or SO4^2- ions to the C6NH2 group of adenine (A) can induce larger C6N electronegativity, which is favor for the C6N/N7 cooperative adsorption on the (Ag)^+ colloid particles.
朱纪春张延会吴良平王祖赓孙真荣
关键词:COLLOIDSDNAGENESSILVER
拉曼光谱研究复方鹿仙草颗粒对SMMC-7721肝癌细胞的作用被引量:5
2008年
应用拉曼光谱研究了不同浓度的鹿仙草溶液与肝癌细胞SMMC-7721的相互作用,通过对药物作用前后细胞的光谱变化进行分析,从而为阐明鹿仙草与肝癌细胞的作用方式提供重要的依据。拉曼光谱显示,加入鹿仙草后,细胞的许多峰都发生了变化。归属于磷酸骨架振动的785和1 092 cm-1的两个峰强度下降,对应碱基A和G的峰1 312和1 585 cm-1等也有不同程度的降低,表明鹿仙草可能插入DNA碱基对之间,使DNA复制受到抑制,导致细胞DNA含量下降,而且会引起DNA单、双链的断裂。同时,研究还发现属于蛋白质的振动峰(1 005,1 360,1 656 cm-1)强度也有不同程度下降,说明蛋白质二级结构以及侧链氨基酸的环境均发生了改变。此外,鹿仙草对细胞的作用效果随浓度增加逐步增强。
张金彦郭建宇蔡炜颖孙真荣
关键词:拉曼光谱鹿仙草肝癌细胞
一种花菁染料超薄膜的激光诱导瞬态光栅被引量:1
2007年
采用旋涂法制备了一种五甲川花菁染料的超薄膜,利用激光诱导瞬态光栅的方法研究染料薄膜的三阶,乃至更高阶的非线性光学特性。通过理论计算得到了该样品在不同浓度下的非线性光学信号的响应时间(59~102 ps),分析表明花菁染料五甲川链上的π-π~*电子跃迁是引起该染料薄膜非线性光学效应(20.5×10^(-13)esu~30.3×10^(-13)esu)的主要原因。研究结果表明激光诱导瞬态光栅是研究介质高阶非线性光学特性一种非常有意义的实验方法。
康海峰元以中孙真荣王祖赓
关键词:非线性光学花菁染料
二溴甲烷相干反斯托克斯拉曼光谱的选择激发增强研究被引量:3
2007年
采用基于遗传算法(Genetic algorithm)的自适应反馈系统,成功实现了二溴甲烷多个拉曼振动模式的选择激发.通过脉冲分析方法(二次谐波频率分辨光谱开关和二次谐波交叉频率分辨光谱开关)(SHG-FROG和SHG-XFROG),在时域和频域上对优化脉冲进行还原和分析,结果表明:空间光学调制器(SLM)将优化脉冲调制成具有负啾啁特性的脉冲串。该选择激发实验的成功实现验证了相干控制自适应系统在研究复杂分子系统方面具有良好的应用前景。
张亮李霞张诗按张向韵邓莉陈果良孙真荣王祖赓
关键词:量子光学
猴子大脑皮层组织的拉曼光谱研究
2010年
猴子的大脑皮层主要由灰质和神经元组成,是大脑中调控行动和思维的区域。选取在生命成长过程中具有代表性的3个年龄段(幼年、成年、老年)猴子的大脑皮层组织,首次测得其拉曼光谱。实验结果显示,3个不同年龄段的猴子大脑皮层的拉曼光谱最明显的差异表现在1 000~1 400 cm^(-1)和2 800~3 000cm^(-1)范围内。随着年龄的增长,归属于脂类的拉曼峰1 313和2 885 cm^(-1)的强度越来越强,而归属于蛋白的拉曼峰1 338和2 932 cm^(-1)的强度却逐渐减弱,并且在老年猴子大脑皮层的拉曼谱中出现了2个归属于脂类的拉曼峰1 296和2 850 cm,I_(1313)/I_(1338)和I_(2885)/I_(2932)的变化趋势很好地描述了这种差异。研究表明,随着年龄的不断增长,猴子大脑皮层中脂类的含量逐渐增加,这样可以很好地说明大脑皮层中脂类的聚积是导致衰老的一个重要原因,为进一步研究人类和动物的生命活动规律、疾病的形成机理提供了很有价值的参考。
朱纪春郭建宇蔡炜颖王祖赓孙真荣
关键词:拉曼光谱猴子大脑皮层不同年龄
Raman spectroscopic identification of normal and malignant hepatocytes被引量:1
2009年
Raman spectroscopy has strong potential for providing non-invasion diagnosis of cancers. In this paper, micro-Raman spectroscopy is used to diagnose one most common liver cancer, hepatocellular carcinoma (HCC). The statistical analyzes, including t-test, principal component analysis (PCA), and linear discriminant analysis (LDA), are performed on the Raman spectra of malignant and normal hepatocytes. The t-test-LDA results show that the 786- and 1004-cm^-1 bands of the malignant and normal hepatocytes are significantly different, and PCA-LDA results show an overall accuracy of 100% for the Raman spectroscopic identification of normal and malignant hepatocytes in our experiment.
郭建宇杜冰钱曼蔡炜颖王祖赓孙真荣
Quantum coherent control of two-photon transitions by square phase-modulation
2008年
A femtosecond laser pulse can be tailored to control the two-photon transitions using the ultra-fast pulse-shaping technique. This paper theoretically and experimentally demonstrates that two-photon transitions in molecular system with broad absorption line can be effectively controlled by square phase-modulation in frequency domain, and the influence of all parameters characterizing the square phase-modulation on two-photon transitions is systemically investigated and discussed. The obtained results have potential application in nonlinear spectroscopy and molecular physics.
张诗按王祖赓孙真荣
Raman spectroscopic investigations on the interactions of gastric cancer cells with 5-fluorouracil被引量:1
2008年
To study the efficacy and side effects of antitumor drug by the method of Raman spectroscopy, the cancerous (SGC-7901) and normal (GES-1) gastric cells were treated with 0, 25-, 100-, and 200-mg/L 5-fluorouracil (5-Fu) for 24 h, respectively, then Raman spectra of cells were recorded. The excitation wavelength was 514.5 nm and the Raman spectra in the region of 500 - 1800 cm^-1 were recorded. For the gastric cancer cells, as the concentration of 5-Pu increases, the band at 1094 cm^-1 attributed to the symmetric stretching vibration mode of PO2^- in the DNA backbone gradually decreases, and the intensity ratio of the band at 1315 cm^-1 to that at 1340 cm^-1 (I1315/I1340) shows the ascending trend, and the ratio of the band area at 1655 cm^-1 to that at 1450 cm^-1 (A1655/A1450) shows the slight ascending trend. For the normal gastric cells, these peaks also appear changes, however, the changes are weaker than those for the cancer cells. In SGC-7901 cells, 5-Pu can interfere with the DNA synthesis and result in the reduction of the DNA content. Besides, it can affect the unsaturation degree of the hydrocarbon chains and alter the external environment of guanine and adenine residues in cancer cells. The changes of Raman spectra for normal gastric cells reveal the side effect of 5-Fu.
郭建宇蔡炜颖杨继朋孙真荣
关键词:PLUTONIUM
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