Isosteviol deravative with formyl group and vinyl moiety 1,an useful and easily available bioactive compound o...
An,Yajie Wu,Ya Liu,Congjun Yang,Jinghua Tao,Jingchao~* (Department of Chemistry,New Drug Research & Development center,Zhengzhou University,Zhengzhou 450052)
＜正＞The asymmetric aldol reaction is one of the most powerful methods for the construction of complex chiral po...
Liu Yu-Xia, SunYa-Nan, Tan Hao-Han, Wu Ya, Ma Zhi-Wei, Tao Jing-Chao Department of Chemistry, New Drug Research and Development Center, Zhengzhou University, Zhengzhou, 450052
A series of novel pyrazole fused heterocyclic derivatives were synthesized via a two-step procedure or a one-pot two step method,and their catalytic DNA cleavage abilities and anti-BVDV activities were also evaluated.The results obtained indicated that compounds 3b-3c could catalyze the cleavage of supercoiled DNA(pUC 19 plasmid DNA) to nicked DNA under physiological conditions with high yields via a hydroiytic mechanism.The studies on anti-viral activities against bovine viral diarrhea virus(BVDV) demonstrated that some of the pyrazole derivatives showed pronounced anti-BVDV activity with interesting EC_(50) values and no significant cytotoxicity.Among them,compound 31 showed the highest antiviral activity(EC_(50) = 0.12 μmoI/L) and was 10 fold more than that of the positive control ribavirin(EC_(50)= 1.3 μmol/L),which provided a potential candidate for the development of anti-BVDV agents.
Chao HanYan-Chun GuoDan-Dan WangXing-Jie DaiFeng-Juan WuHuan-Fei LiuGui-Fu DaiJing-Chao Tao
＜正＞Asymmetric Mannich reactions provide a powerful method for synthesizing optically active β-amino carbonyl u...
An Ya-Jie,Zhang Yun-Xiao,Liu Zhao-Min,Zhang Tao,Tao Jing-Chao Department of Chemistry, New Drug Research and Development Center, Zhengzhou University, Zhengzhou 450052
＜正＞Isosteviol（ent-16-ketobeyeran-19-oic acid 1）,obtained by acid hydrolysis of stevioside,is a tetracyclic dit...
Tao Zhang,Li-Hong Gao,Yan-Ling Yang,Hai-Long Du,Zhong-Tai Song,Jing-Chao Tao~* Department of Chemistry,New Drug Research & Development Center,Zhengzhou University, Zhengzhou 450052,PR China
＜正＞A large amount of interests have been raised in pyrazole derivatives that exhibit wide applications in the ...
Liu,Congjun Wu,Ya Xu,Hao Lan,Yubao Zhao,Hua Tao,Jingchao~* (Department of Chemistry,New Drug Research & Development center,Zhengzhou University,Zhengzhou 450052)
