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国家自然科学基金(30800248)

作品数:4 被引量:24H指数:2
相关作者:郭淼徐莹更多>>
相关机构:杭州电子科技大学更多>>
发文基金:国家自然科学基金浙江省自然科学基金更多>>
相关领域:自动化与计算机技术生物学农业科学更多>>

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4 条 记 录,以下是 1-5
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Simulation of Surface Immobilization on Microelectrode Array for Bio-Impedance Measurement
Microelectrode array provides methods down to cellular level by micromation and integration.However,the quanti...
Y.Xu1 M-E.Xu1 College of life information science&instrument engineering Hangzhou Dianzi University Hangzhou
基于微生物代谢成分的电化学多参数检测平台微泵设计被引量:4
2015年
本文提出一种基于抗生素作用下的微生物膜阻抗及代谢液微量残留物分析的电化学并行检测平台,从量化角度实时反映抗生素对微生物的膜贴附变化及代谢成分的影响。根据现有抗生素电化学检测单元的检测精度,待测生理溶液的进样体积需控制在20μL/min^100μL/min,因此本文针对平台中的关键部分——微泵单元采用有限元设计方法进行了静力场、动力场和流体场的综合分析,确保微泵工作流量的精确性和可控性。分析结果得到设计的微泵在施加20 Hz,±40 V驱动电压时的流量为52.864μL/min,并得出流量与电压及频率的关系式来控制流量的变化;在该基础上对微泵被动阀做了力学特性分析与优化设计,分析得出阀臂固支端优化尺寸为0.4 mm×0.5 mm;最后以商用PSS20型微泵为仿真对象做了相关验证性实验,得到仿真流量的误差率为6.7%,验证了本方法的可行性和准确性,为后期微泵的制作、改进以及多参数检测平台的搭建提供了良好的设计参考。
徐莹胡正添郭淼
SCKF-STF-CN:a universal nonlinear filter for maneuver target tracking被引量:20
2011年
Square-root cubature Kalman filter (SCKF) is more effective for nonlinear state estimation than an unscented Kalman filter.In this paper,we study the design of nonlinear filters based on SCKF for the system with one step noise correlation and abrupt state change.First,we give the SCKF that deals with the one step correlation between process and measurement noises,SCKF-CN in short.Second,we introduce the idea of a strong tracking filter to construct the adaptive square-root factor of the prediction error covariance with a fading factor,which makes SCKF-CN obtain outstanding tracking performance to the system with target maneuver or abrupt state change.Accordingly,the tracking performance of SCKF is greatly improved.A universal nonlinear estimator is proposed,which can not only deal with the conventional nonlinear filter problem with high dimensionality and correlated noises,but also achieve an excellent strong tracking performance towards the abrupt change of target state.Three simulation examples with a bearings-only tracking system are illustrated to verify the efficiency of the proposed algorithms.
Quan-bo GEWen-bin LICheng-lin WEN
Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb
2012年
In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding based on the analysis of simulation and modeling have given rise to electrophysiological models of periglomerular cells,which have an important role in the understanding of the biology of these cells.In this review we provide a brief introduction to the anatomy of the olfactory system and the cell types in the olfactory bulb.We elaborate on the latest progress in the study of the heterogeneity of periglomerular cells based on different classification criteria,such as molecular markers,structure,ion channels and action potentials.Then,we discuss the several existing electrophysiological models of periglomerular cells,and we highlight the problems and defects of these models.Finally,considering our present work,we propose a future direction for electrophysiological investigations of periglomerular cells and for the modeling of periglomerular cells and olfactory information encoding.
YING NanTIAN JianYU SaiNanZHOU JingLING ShuCaiXIA LingYE XueSong
关键词:PATCH-CLAMPHETEROGENEITY
基于Monte-Carlo模型的电极表面处理快速仿真
2014年
微型和集成化的生物传感器为细胞电生理研究提供了强有力的手段。在电极阵列制作工艺上对传感器芯片电极表面进行电镀铂黑处理,可以降低噪声,提高灵敏度。为了量化分析电极表面纳米铂黑粒子的处理效果,本文提出了一种基于Monte-Carlo方法的网格搜索算法,给出了运算优化策略,实现了理想贴附条件下快速模拟一个数量级内粒径分散度在20~200nm范围内均匀分布的纳米粒子贴附于电极上的过程。在电极半径为100μm的尺度下,试验次数n=10时的仿真处理时间从原方法的平均20h优化为0.5h,大大缩短了整个建模过程。应用本文方法进一步研究了在单/多层纳米粒子表面处理时,不同电极尺寸、形状对粒子贴附率和处理均一性的影响。仿真结果表明,理想实验条件下在电极半径小于100μm时,随着电极尺寸的增大,纳米粒子有效贴附率增大,均匀化程度升高,有利于电极阵列重复性的定量评估。在相同电极面积条件下,圆形电极的表面贴附率效果优于方形等形状的电极。
胡正添徐莹郭淼孙智同李燕
关键词:网格搜索
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