Emission of carbon dioxide is considered to be the main cause of the greenhouse effect. Mineral carbonation, an important part of the CCS technology, is an attractive option for long-term CO2 sequestration. In this study, wollastonite was chosen as the feedstock and the feasibility of direct aqueous mineral carbonation in the simulated flue gas was investigated via a series of experimental studies carried in a stirred reactor. X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), ion chromatography (IC) and thermal decomposition were used to determine the carbonation conversion. The influences of various factors, including reaction temperature, reaction pressure, solution composition, heat-treatment and particle size, were discussed. Concurrently, the effects of SO2 and NO presented in simulated flue gas were also investigated and a possible mechanism was used to explain the results. Experimental results show that reaction temperature, reaction pressure and particle size can effectively improve the carbonation reaction. Addition of 0.6 M NaHCO3 was also proved to be beneficial to the reaction and heat-treatment is not needed for wollastonite to get a higher carbonation conversion. Compared with carbonation in purified CO2 gas, CO2 sequestration directly from simulated flue gas by mineral carbonation is suggested to have a certain degree of economic feasibility in the conditions of medium and low-pressure. A highest carbonation conversion of 35.9% is gained on the condition of T=150°C, P=40 bar and PS <30 μm in distilled water for 1h.