Event-related potentials (ERPs) are objective electrophysiological indicators that can be used to assess cognitive processes in the human brain. Psychiatric researchers in China have applied this method to study schizophrenia since the early 1980s. ERP measures used in the study of schizophrenia include contingent negative variation (CNV), P300, mismatch negativity (MMN), error-related negativity (ERN) and auditory P50 inhibition. This review summarizes the main findings of ERP research in patients with schizophrenia reported by Chinese investigators.
精神疾病与大脑皮质兴奋性异常有关,其发病机制可能与γ-氨基丁酸（GABA）神经递质通路的功能失调有关.经颅磁刺激（transcranial magnetic stimulation,TMS）技术可以非侵入地、活体评估GABA能中间神经元介导的皮质兴奋性,为精神疾病提供潜在的神经电生理生物标记.目前,经颅磁技术已经被应用于评估多种精神疾病的大脑皮质兴奋性,包括精神分裂症、抑郁症、孤独症、强迫症等,取得了有意义的进展.
