原发性中枢神经系统淋巴瘤（primary central nervous system lymphoma,PCNSL）是指原发于脑、脊髓、眼或软脑膜的淋巴瘤,大多数PCNSL为B细胞起源,形态及病理特征与弥漫大B细胞淋巴瘤（diffuse large B-cell lymphoma,DLBCL）相似,WHO（2008）造血与淋巴组织肿瘤分类已经将原发于中枢神经系统（CNS）的DLBCL归类为一个独立实体.
Background: Primary central nervous system lymphoma(PCNSL) is a rare kind of non-Hodgkin lymphoma. Rituximab combined with high-dose methotrexate, cytarabine and dexamethasone (R-MAD regimen) were reported effective for PCNSL patients. Rituximab can cause several side effects, including fever, chills and rigors. Case presentation: In this case report, we demonstrate rituximab-induced interstitial pneumonitis in a PCNSL patient who has been treated with R-MAD regimen. The patient recovered after treatment and she remains complete remission after following consolidation chemotherapy. Conclusions: Here is no report of potential fatal complications of Rituximab like interstitial pneumonitis nowadays in PCNSL patients. As Rituximab is widely used, physicians should raise their awareness of this rare complication and detect RTX-ILD in early stage.
Yuchen WuXuefei SunJing LiuJun QianXueyan BaiYuedan ChenYuanbo Liu
