Three novel intercalation agents were synthesized for the first time,which arose from oleic acid diethylenetriamine or triethylenetetramine 3-chloro-2-hydroxypropy trimethylammonium choride(CHPTA)and chloroethanol.Organophilic vermicullites were synthesized from sodium type vermiculite by cation exchange with new intercalation agents.The results of X-ray diffraction study showed that the gallery distance of the organophilic vermiculite was enlarged from 1 nm to 5 nm or more.A new idea of making design for intercalation agent was provided.