AIM: To explore whether the same corneal curvature parameters and anterior chamber depth measured by Pentacam and VX120 have a good consistency and can replace each other. METHODS: This study enrolled 140 eyes of 70 patients ranging in age from 19 to 53 y. All eyes underwent a comprehensive ophthalmologic examination including an anterior segment analysis with the VX120 system(Visionix-Luneau Technologies, Chartres, France) and Pentacam(Oculus Optikgerate GmbH) respectively. The comparison on corneal curvature parameters was done between Pentacam and VX120 using clustered signed rank test;the interclass correlation coefficients(ICC) with 95% confidence intervals(CI) was calculated for each parameter between Pentacam and VX120;the BlandAltman plot of each parameter was supplemented. RESULTS: The anterior corneal curvature measured by VX120 was Ks: 44.00±1.78 D, KsAt: 89.45±22.18, Kf: 42.84±1.58 D, KfAt: 93.91±79.34;which measured by Pentacam was Ks: 43.80±1.82 D, KsAt: 91.17±21.40, Kf: 42.61±1.64 D, KfAt: 91.16±78.69. There was statistical difference between Pentacam and VX120 for anterior corneal curvature parameter(P<0.001). The posterior corneal curvature measured by VX120 was Ks:-6.42±1.23 D, KsAt: 91.00±23.45, Kf:-5.85±1.24 D, KfAt: 95.93±79.11;which measured by Pentacam was Ks:-6.44±0.32 D, KsAt: 92.24±11.75, Kf:-6.01±1.05 D, KfAt: 74.43±80.64. There was statistical difference between Pentacam and VX120 for posterior corneal curvature parameters(P<0.001). Anterior chamber depth(ACD) measured by Pentacam and VX120was statistically different. Pentacam and VX120 achievedhigh consistency only on corneal anterior surface, including Ks and Kf. The ICCs were 0.96(95%CI: 0.95, 0.97) and 0.95(95%CI: 0.94, 0.97) respectively. For other corneal surface curvature parameters, all ICCs of between Pentacam and VX120 were below 0.87. Bland-Altman plots indicated oflow consistency of corneal surface curvature parameters measured by Pentacam and VX120. CONCLUSION: The corneal curvature parameters and anterior
