Micro RNAs（mi RNAs） are known to regulate post-transcriptional gene expression.They are involved in carcinogenesis and tumor progression.The aim of this study was to explore the micro RNA-m RNA regulatory network in esophageal squamous cell carcinoma（ESCC） using comprehensive computational approaches.In this study we have selected a total of 11 mi RNAs from one previously reported study in ESCC.The m RNA targets of these mi RNAs were predicted using various algorithms.The expression profiles of these m RNA targets were identified on DNA microarray experiment dataset across ESCC tissue samples.Based on the mi RNA-m RNA regulatory relationships,the network was inferred.A total of 23 mi RNA-m RNA regulatory interactions,with 11 mi RNAs and 13 m RNA targets,were inferred in ESCC.The mi RNA-m RNA regulatory network with increased confidence provides insights into the progression of ESCC and may serve as a biomarker for prognosis or the aggressiveness of ESCC.However,the results should be examined with further experimental validation.
Jie ZHAOBi-cheng ZHANGLi-fang YUWei-xing WANGYong ZHAOZhi-guo RAO
辅助性T细胞(helper T cell,Th)在机体免疫应答和免疫调节中发挥着重要作用。Th9细胞通过特异地分泌白细胞介素9(IL-9)和IL-10作用于不同的炎性细胞和组织细胞,产生不同的生物学效应,且不同条件下对其他细胞亚群也发挥不同的免疫调节作用。Th9细胞在肿瘤免疫应答中的作用及机制也逐渐被临床所关注,包括抗肿瘤作用、在肺癌恶性胸腔积液中的免疫调节作用及对丙型肝炎病毒的清除作用,提示临床可通过阻断IL-9的表达来调节肿瘤免疫。
