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基于石墨烯/金纳米星光敏复合物的高效光疗及其光声成像研究: 兼具成像和治疗功能的一体化纳米复合物是高效诊治癌症的新型有效途径之一。本文成功构建了一种稳定的具有宽近红外吸收窗口、高效载药和光声成像能力的石墨烯/金纳米星光敏复合物（GO-Au NS/ce6）,用于成像指导的单波长激光...; 吴春惠王莲慧李丹田园官晓天杨红刘贻尧; 关键词：石墨烯

An efficient method of isolating mesenchymal stem cell from umbilical cord: ＜正＞Mesenchymal stem cells（MSCs） are widely applied for clinical diseases and tissue engineering.Umbilical cord...; Liwu ZhongYiyao Liu; 文献传递

Roles for αvβ3 and GP lIb/IIIa integrins in MDA-MB-231 cell invasion and shear flow-induced mechanotransduction: ＜正＞Introduction Hematogenous metastasis is the mainly leading cause of death in breast carcinoma patients. A b...; Fenglong ZhaoLi LiLiuyuan GuangHong YangChunhui WuYiyao Liu; 文献传递

一种兼具化疗与光动力治疗功能的石墨烯纳米复合药物的研究: 光动力治疗是一种基于光敏剂的典型微创治疗方法,在肿瘤等多种疾病的治疗中具有重要的应用,但其疗效却由于光敏剂的疏水性、易聚集、1O2产率低等因素而大大受到限制[1]。本文制备了一种具有光动力治疗和化疗活性的纳米复合药物,即...; 贺秋铭吴春惠朱安妮杨红刘贻尧; 关键词：光动力治疗阿霉素酞菁锌; 文献传递

肿瘤细胞间相互作用：Notch-1信号转导与调控机制被引量：7: 2016年; Notch-1信号通路在细胞分化、发育以及增殖、凋亡方面起重要作用,并参与肿瘤的发生发展,与肿瘤的侵袭、运动和转移过程密切相关。活化的Notch-1信号通路能够直接或间接调控细胞的增殖和迁移,促进肿瘤细胞发生上皮细胞间充质转换,并维持其间充质特性,增强肿瘤细胞的黏附能力。同时,Notch信号通路与PI3K/Akt、NF-κB等途径交互作用,将信号级联放大,从而加强调控肿瘤细胞的恶性行为。多种实体瘤中存在异常活化的Notch-1信号通路。从Notch的结构和功能、Notch-1信号通路与肿瘤发生和转移的关系、Notch-1调控肿瘤转移的分子机制与调控网络和以Notch为靶点的肿瘤治疗5个方面进行综述。阐明Notch-1信号通路在肿瘤转移过程中的作用与调控机制以及目前针对Notch-1信号通路的治疗策略,能够为肿瘤的病理机制和临床治疗研究提供参考信息。; 李莉熊妮娅张婧杨红吴春惠刘贻尧; 关键词：细胞间相互作用肿瘤细胞细胞黏附肿瘤转移

Near-Infrared Light Responsive Graphene based Nanocomposites for Synergistic Cancer Phototherapy: ＜正＞Phototherapy is currently being attached enormous attention in the area of cancer nanomedicine because of i...; Chunhui WuDan LiLianhui WangAnni ZhuHong YangYiyao Liu; 文献传递

Low shear stress induce breast cancer MDA-MB-231 cell motility and cytoskeleton remodeling via PI3K/Akt/mTOR/p70S6K signal pathway: ＜正＞Cancer cell metastasis is a mainly leading cause to death of malignant carcinoma patients.Hematogenous meta...; Fenglong ZhaoNiya XiongYu ChenJing ZhangShun LiHong YangChunhui WuYiyao Liu; 文献传递

基于石墨烯/金纳米星光敏复合物的高效光疗及其光声成像研究: 兼具成像和治疗功能的一体化纳米复合物是高效诊治癌症的新型有效途径之一。本文成功构建了一种稳定的具有宽近红外吸收窗口、高效载药和光声成像能力的石墨烯/金纳米星光敏复合物(GO-Au NS/ce6),用于成像指导的单波长激光...; 吴春惠王莲慧李丹田园官晓天杨红刘贻尧; 关键词：石墨烯; 文献传递

兼具光疗/化疗的石墨烯纳米复合药物的制备及其抗癌活性研究: 癌症是严重危害人类健康和生命的重大疾病之一。癌症多模疗法集两/多种治疗方法的优点,对于癌症的高效治疗、抑制转移和预防复发具有重要的作用。本文构建了一种兼具光热治疗与化疗的石墨烯基纳米复合物,即以聚丙烯酰胺(PAH)修饰的...; 朱安妮李丹吴春惠杨红刘贻尧; 关键词：石墨烯化疗; 文献传递

Roles for α_Vβ_3 and GP Ilb/Illa integrins in MDA-MB-231cell invasion and shear flow-induced mechanotransduction: 2013年; Introduction Hematogenous metastasis is the mainly leading cause of death in breast carcinoma patients.A better understanding of the underlying molecular and cellular mechanisms is crucial for the development of effective treatment for metastatic breast cancer^[1].It has been well established that cell adhesion and invasion is mediated by a variety of transmembrane proteins,including integrins,cadherins,selectins,and intercellular adhesion molecules.Among these adhesion molecules,the integrins and their downstream signaling pathways have been extensively studied^[2].On the other hand,the specific events determining tumor cell interactions with endo-; Fenglong ZhaoLi LiLiuyuan GuangHong YangChunhui WuYiyao Liu; 关键词：ROLES INTERCELLULAR TRANSMEMBRANE

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国家自然科学基金(11272083)