Informative proteins are the proteins that play critical functional roles inside cells.They are the fundamental knowledge of translating bioinformatics into clinical practices.Many methods of identifying informative biomarkers have been developed which are heuristic and arbitrary,without considering the dynamics characteristics of biological processes.In this paper,we present a generative model of identifying the informative proteins by systematically analyzing the topological variety of dynamic protein-protein interaction networks(PPINs).In this model,the common representation of multiple PPINs is learned using a deep feature generation model,based on which the original PPINs are rebuilt and the reconstruction errors are analyzed to locate the informative proteins.Experiments were implemented on data of yeast cell cycles and different prostate cancer stages.We analyze the effectiveness of reconstruction by comparing different methods,and the ranking results of informative proteins were also compared with the results from the baseline methods.Our method is able to reveal the critical members in the dynamic progresses which can be further studied to testify the possibilities for biomarker research.
针对自适应中值滤波在窗口迭代过程中存在像素点重复参与运算导致算法复杂度较高的问题,提出了一种改进的中值滤波算法.首先依据有效像素点与窗口中心点间的坐标距离来快速确定最佳滤波窗口尺寸,避免了窗口迭代造成的像素点重复排序;之后对窗口内的有效像素点进行取中值操作,有效削弱了噪声点的干扰,进一步提升了图像滤波的质量.经实验验证,与自适应中值滤波算法比较,复杂度显著降低,峰值信噪比(peak signal to noise ratio,PSNR)值平均提高10 d B左右.和同类文献比较在算法复杂度和图像降噪效果间做出了一个较佳的权衡.最后将该算法应用于Kinect深度图降噪上获得了不错的效果.
