A convenient and highly efficient conversion of 1β-OH-trans-vitamin D3, a main byproduct in synthesis of active vitamin D3, to 1α-OH-trans-vitamin D3 is reported. The conversion could be accomplished in 1 minute with 90% yield.
Yong Bin HANJin Ping CHENYing Ying LIBai Ning LIUGuo Qiang YANGYi LI
A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity inoxidation step than classical protecting groups. The stereochemistry control is favored by usinghigh crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesisof vitamin D system.
Yong Bin HANJin Ping CHENBai Ning LIUGuo Qiang YANGYi LI
