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国家自然科学基金(10774069)

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发文基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Influence of temperature and diffusive entropy on the capture radius of fly-casting binding被引量:1
2011年
The recognition and binding of proteins through the "fly-casting" mechanism are important biological processes. In this paper, a physical model for fly-casting binding is described based on the capillarity theory for protein chains. It is found that the capture radius for the fly-casting binding process is maximized at the transition temperature at which the free energy of the monomeric extended state of the protein equals that of the folded state. The factors related to the folding barrier or binding affinity do not change the condition needed to realize the optimization for fly-casting processes. These results will aid in the comprehensive understanding of binding processes.
CHANG LeGUO XinLuZHANG JianWANG JunWANG Wei
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