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国家自然科学基金(81201057)

作品数:9 被引量:30H指数:3
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相关机构:上海交通大学兰州大学第一医院上海市虹口区精神卫生中心更多>>
发文基金:国家自然科学基金甘肃省自然科学基金更多>>
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心境稳定剂在精神疾病治疗中的应用被引量:3
2014年
目前临床上常用的心境稳定剂包括锂盐、抗惊厥药物和非典型抗精神病药物。此外,现还新上市了一些具有潜在心境稳定作用的药物或辅助用药。本文概要介绍主要心境稳定剂及其在精神疾病治疗中的应用。
郭晓云王韵吴彦
关键词:心境稳定剂精神疾病双相情感障碍精神分裂症
新的气体信号分子硫化氢的中枢心血管效应被引量:5
2016年
硫化氢最初被认为是一种可抑制中枢神经系统和呼吸而致人死亡的无色、有臭鸡蛋味的毒性气体。后来的研究表明牛、鼠和人等哺乳动物脑组织中存在高浓度的内源性硫化氢(50~160μmol/L)。内源性硫化氢能增加神经细胞内环磷酸腺苷水平,增强N-甲基D-天门冬氨酸(N-methyl D-aspartate,NMDA)受体介导的内向电流,
彭超鲁彦柴琛
关键词:心血管效应气体信号分子内源性硫化氢ASPARTATE延髓腹外侧区
内源性二氧化硫在重症急性胰腺炎大鼠的分布被引量:3
2015年
目的 探讨内源性二氧化硫(sulfur dioxide,SO2)在重症急性胰腺炎(severe acute pancreatitis,SAP)大鼠胰腺组织、肝组织、肾脏组织、肺组织及血清中的分布与水平变化.方法 雄性SD大鼠32只,随机数字法分为假手术组、SAP 3 h组、SAP 6 h及SAP 12 h组(每组8只).SAP大鼠模型通过胰胆管逆行注射5%牛磺胆酸钠制作.造模后3h、6h及12h处死大鼠,酶联免疫吸附试验测定胰腺组织、肝组织、肺组织、肾组织及血清标本SO2.结果 SAP 3 h大鼠胰腺组织、肝组织、肺组织、肾组织及血清中SO2含量分别为(1.62±0.11) μmol/g、(1.72±0.14) μmol/g、(1.65±0.11) μmol/g、(1.12±0.06)μmol/g、(14.61±0.68) μmol/g.与假手术组比,差异无统计学意义(P>0.05).SAP 6 h大鼠胰腺组织、肝组织、肺组织、肾组织及血清中SO2含量分别为(1.89 ±0.17) μmol/g、(1.92±0.16) μmol/g、(1.91±0.15) μmol/g、(1.30±0.10) μmol/g、(16.80±1.27) μmol/g.与假手术组相比,各组织SO2含量升高,差异有统计学意义(均P <0.05).SAP 12 H胰腺组织、肝组织、肺组织、肾组织及血清中SO2含量分别为:(2.31±0.23) μmol/g、(2.22±0.15) μmol/g、(2.17±0.07) μmol/g、(1.55±0.11) μmol/g、(16.80±1.27)μmol/g.与假手术组相比,SO2含量升高,差异有统计学意义(P<0.05).结论 SAP大鼠体内SO2水平高于正常,可能与重症急性胰腺炎有一定的相关性.
王奇坤岳建云鲁彦张娈娈郭晓云柴琛周荣
关键词:二氧化硫重症急性胰腺炎胰腺
Is depression the result of immune system abnormalities?被引量:1
2017年
抑郁障碍病因仍不清楚。本文综述了相关文献,提供了炎症信号和细胞因子在抑郁障碍的发病机制中的作用、及抗炎机制药物的辅助性治疗对提高抑郁症治疗疗效、改善预后的证据,并进一步探讨了抑郁障碍发病机制与免疫异常的可能联系。
郭晓云江开达
关键词:免疫系统信号转导抗炎药物
PAID study design on the role of PKC activation in immune/inflammation-related depression:a randomised placebo-controlled trial protocol被引量:1
2021年
Background Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression.Microglia activation can lead to an increase in the levels of proinflammatory cytokines,including TNF-α,which leads to neuronal apoptosis in the specific neural circuits of some brain regions,abnormal cognition and treatment-resistant depression(TRD).Protein kinase C(PKC)is a key regulator of the microglia activation process.We assume that the abnormality in PKC might result in abnormal microglia activation,neuronal apoptosis,significant changes in emotional and cognitive neural circuits,and TRD.In the current study,we plan to target at the PKC signal pathway to improve the TRD treatment outcome.Methods and analysis This is a 12-week,ongoing,randomised,placebo-controlled trial.Patients with TRD(N=180)were recruited from Shanghai Mental Health Center,Shanghai Jiao Tong University.Healthy control volunteers(N=60)were recruited by advertisement.Patients with TRD were randomly assigned to‘escitalopram+golimumab(TNF-αinhibitor)’,‘escitalopram+calcium tablet+vitamin D(PKC activator)’or‘escitalopram+placebo’groups.We define the primary outcome as changes in the 17-item Hamilton Depression Rating Scale(HAMD-17).The secondary outcome is defined as changes in anti-inflammatory effects,cognitive function and quality of life.Discussion This study might be the first randomised,placebo-controlled trial to target at the PKC signal pathway in patients with TRD.Our study might help to propose individualised treatment strategies for depression.Trial registration number The trial protocol is registered with ClinicalTrials.gov under protocol ID 81930033 and ClinicalTrials.gov ID NCT04156425.
Xiaoyun GuoRuizhi MaoLvchun CuiFan WangRubai ZhouYun WangJia HuangYuncheng ZhuYamin YaoGuoqing ZhaoZezhi LiJun ChenJinhui WangYiru Fang
关键词:PLACEBOINFLAMMATIONVITAMIN
丙戊酸盐治疗双相情感障碍的研究进展被引量:11
2014年
作为心境稳定剂,丙戊酸盐治疗各型双相情感障碍均有一定的疗效。近年来对各型双相情感障碍患者进行的临床研究证实:丙戊酸盐能改善躁狂症状;联合镇静药物治疗可有效改善抑郁症状;联合抗抑郁药物预防抑郁发作的疗效优于锂盐。丙戊酸盐与其他心境稳定剂联合治疗快速循环型双相情感障碍患者时可能更有益,也更适用于非快速循环型双相情感障碍患者的长程治疗。
张桦郭晓云吴彦
关键词:丙戊酸盐心境稳定剂双相情感障碍
Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI被引量:1
2020年
Background The prevalence of Alzheimer's disease(AD)comorbid with depression is common.However,the mechanisms of AD with depression remain unclear.Aims To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging(rs-fMRI).Methods 154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October 2016.According to whether the core symptoms of depression were present,patients were divided into two groups,22 patients with AD with depression(AD-D)and 52 patients with AD without depression(AD-nD).The amplitude of low frequency fluctuations(ALFF)was compared between two groups by performing independent-samples f-test.Results Compared with the AD-D group,increased ALFF values in the bilateral superior frontal gyrus,left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group.The brain activity in the AD-nD group in the bilateral superior frontal gyrus,left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.Conclusions Resting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.
Yuzhu MuYumei LiQi ZhangZhongxiang DingMei WangXingguang LuoXiaoyun GuoMaosheng Xu
关键词:ALZHEIMERPATIENTS
合并改良电抽搐治疗对不同年龄首发精神分裂症患者认知功能的影响被引量:5
2014年
目的探讨单纯药物治疗及合并改良电抽搐治疗(MECT)治疗对首发精神分裂症患者精神病性症状及认知功能的影响。方法选取住院治疗的首发精神分裂症患者104例,根据年龄分为低年龄组(18~26岁,n=52)和高年龄组(39~46岁,n=52),两组再根据治疗方法的不同分别分为单纯药物组和合并MECT组。对各组患者进行治疗前以及治疗后3、6、12周的阳性与阴性症状量表(PANSS)评分以及威斯康星卡片分类测验(WCST),并对其结果进行统计分析。结果治疗3周后,低年龄层合并MECT组患者PANSS减分值显著高于单纯用药组,差异有统计学意义(P〈0.001);治疗3周和6周后,高年龄层合并MECT组PANSS减分值也显著高于单纯用药组,差异有统计学意义(P〈0.001)。在治疗3周后的WCST测验中,低年龄层合并MECT组患者的完成应答数、正确应答数和完成分类数均明显高于单纯用药组,高年龄层合并MECT组患者的持续错误数明显低于单纯用药组,差异均有统计学意义(P〈0.05)。结论MECT能较快改善患者的精神病性症状,并能相应提高不同年龄患者的认知功能。
许蔚倩齐钢桥陈兴阳齐文耀朱新陈红英郭晓芸
关键词:首发精神分裂症
Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels
2019年
LTCCS ARE IMPLICATED IN THE PATHOLOGY OF BIPOLAR DISORDER Bipolar disorder (BPD) is a common mental illness with significant morbidity and mortality.1 Although evidence have suggested changes in oxidative stress, dopamine and inflammation in BPD, it is hard to define the aetiological mechanism of BPD clearly. Recently, some but not all candidate gene association studies, family-based association studies, linkage studies, genome-wide association studies (GWASs) and meta-analyses showed that mutation of L-type voltage-gated calcium chan? nels (LTCCs) gene CACNAlCis implicated in the mechanism of BPD.'-8 These findings support the possibility that BPD might have calcium channelopathy.
Xiaoyun GuoDengtang LiuTong WangXingguang Luo
关键词:AETIOLOGYBIPOLARDISORDERCONTRIBUTIONCALCIUM
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