Background Several kinds of intercellular adhesion molecules closely relate to hepatitis B. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, hyperplasia and activation of T lymphocytes. In this study, we explored the relationship between the expression of CD58 in liver tissue and chronic hepatitus B infection. Methods We determined the expression of the CD58 molecule on the surface of hepatoc^es by using immunohistochemistry and the levels of serum HBV DNA from patients with HBV infection and from normal controls. The biochemical parameters of hepatic function were analyzed as well. Results CD58 expression in hepatocytes significantly increased with the severity progression of chronic HBV infection. The IOD levels （log10） of CD58 in the control, mild, moderate, and severe chronic HBV infection groups were 0, （7.20±4.64）×10^3, （25.63±7.41）×10^3 and （37.47±11.17）×10^3 respectively （P〈O.05 compared with the control group, respectively） Conclusion CD58 probably increases cell mediated immunity to eliminate hepatitis B virus and leads to damage of hepatocytes.
WANG Ping QI Bao-tai CHEN Ping HE Lin-jing LI Jie JI Yu-qiang XIE Ming
It was previously reported that several kinds of intercellular adhesion molecules are closely related to chronic HBV infection. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. In this study, we detected the level of CD2 expressed on the surface of PBMC, the expression level of CD2 mRNA in PBMC and the percentage of CD2 positive cells in PBMC of patients with chronic HBV infection and compared them with the expression level of normal controls. We also determined the level of serum HBV DNA from patients with chronic HBV infection and from normal controls. The clinical characteristics of hepatic function were tested as well. The results showed that the expression of CD2 significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection. Cellular ＆ Molecular Immunology.
Jie Li Baotai Qi Ping Chen Linjing He Ping Wang Yuqiang Ji Ming Xie
