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国家自然科学基金(39860030)

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相关作者:吴磊张永虹张宝初余奇余万霰更多>>
相关机构:启东市肝癌防治研究所南昌大学第一附属医院南昌大学第二附属医院更多>>
发文基金:国家自然科学基金更多>>
相关领域:医药卫生更多>>

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The mode of yearly biological cycle of malignant growth of hepatocellular carcinoma on computed tomography
2003年
OBJECTIVE: To detect the mode of yearly biological cycle of malignant biological behavior of hepatocellular carcinoma (HCC). METHODS: Twenty-one kinds of CT signs reflecting various degrees of malignant biological behavior were determined. A total of 360 patients were collected by random sampling of 30 patients each month. CT signs of each patient were fitted in corresponding group of yearly cyclic data respectively by cosine curves and analysed in terms of sequence characteristics (cosinor). RESULTS: With a 95% confidence, 10 CT signs showed biological rhythm (P<0.05). The acrophase of CT features for highly-invasive growth concentrated between -60° and -120° from March to April. For low-invasive growth, however, the CT features were relatively low and concentrated between -180° and -270° from July to September. No acrophase was shown between -120° and -180° from May to June, and between -270° and -330° from October to November. CONCLUSION: Between CT signs of the highly-invasive and those of low-invasive growth of HCC, a sequential difference in biological cycles can be observed.
Wan-Xian Yu
关键词:CHRONOBIOLOGY
肝癌死亡率显著差异地区肝癌病例HBV标记对比
2008年
[目的]随着病毒环境基因组研究的进展,已发现HBV基因组序列存在明显地理差异,本研究对我国肝癌死亡率最高地区之一的江苏省启东市和肝癌死亡率一般性地区之一的江西省南昌市的生活原地肝癌病例的HBV感染免疫学标记进行对比分析,从HBV感染机制上探索我国肝癌死亡率具有显著差异的原因,为我国HBV并肝癌的遗传性环境基因组研究开拓思路。[方法]选择启东与南昌生活原地的肝癌病例,采集HBV感染免疫学标记(HBsAg、抗-HBs、HBeAg、抗-Hbe、抗-HBc)阳性数据,随机输入SPSS10、0软件程序,排列出感染模式,用卡方检验方法对两地区模式标记及单项标记进行对照性统计学分析。[结果]南昌高于启东的模式有:I型HBsAg(+)、HBeAg(+)抗-HBc(+),Ⅱ型HBsAg(+)、抗-HBe(+)、抗-HBc(+)及Ⅲ型HBsAg(+)、抗-HBc(+)。启东高于南昌的模式有:IV型HBsAg(+)、HBeAg(+),V型抗-HBe(+)抗-HBc(+)及VI型抗-HBc(+),均P﹤0.05。5项免疫标记单列进行比较统计,HBsAg(+)存在统计学差异(P﹤0.05),南昌高于启东。[结论]南昌与启东肝癌病例的HBV感染模式存在明显差异,关键是启东肝癌病例HBsAg表达率极低。
余万霰张永虹余奇张宝初吴磊
关键词:肝癌HBV
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