＜正＞Poly（D,L-lactide-co-glycolide）（PLGA）is a biodegradable and biocompatible polymer material for drug deliver ...
Hong Yang,Kai Li,Zhonghua Liu,Zhenglong Ren,Yiyao Liu, Department of Biophysics,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu,Sichuan 610054,P.R.China
The use of nanotechnology in drug delivery is a rapidly expanding field. Biodegradable or nontoxic nanomaterials have the most promising application potentials in nanomedicine. Herein, we report a novel core-shell nanoparticle with double shell coatings (silica and poly(D,L-lactide-co-glycolide) (PLGA)) with the total shell thickness of (8.7 ± 1.3) nm. The outer shell of PLGA is biodegradable and used for controlled and sustained release, and the inner shell of silica is mesoporous for the preservation of the chemical radiation therapeutic of methyl viologen (MV), an oxidant that produces reactive oxygen species during cancer radiation therapy. The dissolution time course data and transmission electron microscopy images showed that the novel nanoparticles (Au@SiO2&PLGA) have been successfully prepared, and silica and PLGA coated well the gold (Au) template surfaces. Nano- capsules (MV@SiO2&PLGA) were obtained after the gold templates were dissolved using sodium cyanide. The sustained release property was characterized through detecting fluorescence quenching time course of fluorescent isothiocyanate after mixing with MV@SiO2&PLGA nanocapsules that encapsulate MV molecules. The sustained release of MV molecules could be extended to approximately four weeks. This novel delivery system has high potential in future application for the delivery of therapeutic drugs, particularly for the treatment of cancer by radiation therapy.
YANG HongMIYOSHI HirokazuLOU ChangChunREN ZhengLongLIU YiYao
<正>Endothelial dysfunction is characterized by some specific adhesion molecules up-regulation on endothelium s...
Yiyao Liu,Lie Zhang,Hong Yang(Department of Biophysics,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054)
