Synthetic studies on the construction of 7-O-methylquercetin from quercetin in 36% yield in four steps is reported, this strategy relies on one hand on the selective protection of the catechol group with dichlorodiphenylmethane using dephenyl ether as a solvent, on the other hand, on the selective protection of the 3-hydroxyl group with benzyl bromide, these two different protecting groups can be removed under the same hydrogenation.
Nian Guang LIZhi Hao ShiYu Ping TangJian Ping YangTu Lin LuFeng ZhangYi Wen HuangZhen Jiang WangJin Ao Duan
