Linear diribonucleoside phosphotriester is an important intermediate for synthesizing biologically important compounds,such as cyclic bis(3'-5') diguanylic acid(c-di-GMP) and its analogues. Atropisomerism of diastereomers generated by the chiral center of the P atom,which results in the doubling of signals in ^(31)P NMR.The data of ^(31)P NMR at different temperature are presented,and thereafter the reason is discussed.
Lu-Xin NaXu-Lin SunMeng WangKun-Feng LiLei XingZhuo ChenZhu GuanZhen-Jun Yang
