A compact line scanning quasi-confocal ophthalmoscope (LSO) is presented in this letter. Compared with a conventional scanning laser ophthalmoscope (SLO), the bench-top LSO significantly reduces the size, complexity, and cost of SLO utility with routine use. The LSO uses one moving part to produce high-contrast and high-resolution quasi-confocal images with nearly the same performance as a SLO. The LSO has a moderate field of view (～10 ), which enables images of the macula, the optic nerve head, and other targets to be obtained more quickly and efficiently. An image of the optic nerve head is taken in a preliminary investigation on human subjects. Individual nerve fiber bundles and vessels are resolved at a shallow depth, with a lateral resolution of nearly 10 μm.
A custom built 1310 nm center wavelength swept source optical coherence tomography instrument was used to measure morphological changes in treated and newly diagnosed untreated glaucomatous human Schlemm’s canal(SC).Thirty-seven primary open-angle glaucoma patients were divided into two groups depending on the patients having been treated or not.The statistical results showed that there were significant differences between the treated and untreated groups’SC areas(treated,7935.6875±680.003μm2;untreated,3890.71875±871.49844μm2;P<0.001),the circumferences(treated,580.37891±44.96529μm;untreated,381.9026±41.22123μm;P<0.001),and the long diameters(treated,272.87806±25.7254μm;untreated,185.24047±19.72786μm;P<0.001).We hypothesize that,after drug treatment,the SC will expand and the morphometric values especially the areas will become larger,thus helping to reduce intraocular pressure.
SHI Guo HuaFU Ling LingLI Xi QiJIANG Chun HuiZHANG Yu Dong
