A polyamide containing N-methylpyrrole (Py) and N-methylimidazole (Im) amino acids was synthesized by coupling two of the four-ring oligopeptide chains using DCC/ HOBT as promoting additives. The structure of the polyamide was confirmed by IR, NMR and MS spectra.
The fluorescence spectra of the interaction between four new distamycin analogs and DNA from herring sperm have been studied in detail. The fluorescence quenching of the DNA by the analogs was observed, and the fluorescence intensity of the DNA was attenuated exponentially with the increasing of the analogs concentration.
Han LIANGJing Jian LIXiao Dong LIFei Li TANGGu YUAN
