膀胱癌(Bladder Cancer, BC)位列全球最常见的十种癌症之中,其患病率与致死率均处于较高水平。长链非编码核糖核酸(lncRNAs, 即Long non-coding RNAs)指的是那些核苷酸数量在200至100,000个之间的核糖核酸分子,这类分子几乎不编码蛋白质或仅有极低的编码潜力,并且近年来已经成为了研究热点。近年来,lncRNA逐渐被发现参与到多种生理病理过程之中,并与多种疾病的发生发展有关,其中尤其以癌症为甚。在膀胱癌中,lncRNA同样起到了关键的作用。它既可作为肿瘤抑制基因,也可能成为肿瘤促进基因。有充分证据表明,lncRNA能作为竞争性内源RNA (Competing endogenous RNA, ceRNA)与微小RNA (microRNA, miRNA)结合,进而调控靶基因的表达。这已被认为在许多类型的肿瘤中发挥着不可或缺的作用。本文就lncRNA在膀胱癌中的ceRNA机制作一综述。Bladder cancer (BC) ranks among the top ten most prevalent cancers globally, characterized by high incidence and mortality rates. Long noncoding RNAs (lncRNAs) are a class of RNA molecules with transcript lengths ranging from 200 to 100,000 nucleotides;they either lack or have minimal protein-coding capacity. In recent years, lncRNAs have garnered significant attention due to their involvement in various physiological and pathological processes, and they are increasingly recognized as being closely associated with the pathogenesis of numerous diseases, particularly in oncology. Within the context of bladder cancer, lncRNAs play a pivotal role, functioning both as tumor suppressors and oncogenes. Mounting evidence suggests that lncRNAs can act as competitive endogenous RNAs (ceRNAs) by binding to microRNAs (miRNAs), thereby influencing and modulating the expression of target genes, a role considered essential in multiple types of tumors. This review examines the role of the lncRNA ceRNA mechanism in bladder cancer.
